CUG-BP1 Recombinant Rabbit Monoclonal Antibody [JE40-85] (HA722552)

UNIPROT #

Q92879

PROTEIN NAME

CUG-BP1

SYNONYMS

50 kDa Nuclear polyadenylated RNA binding protein antibody;50 kDa nuclear polyadenylated RNA-binding protein antibody;Bruno like 2 antibody;bruno like protein 2 antibody;Bruno-like protein 2 antibody;BRUNOL 2 antibody;BRUNOL2 antibody;CELF 1 antibody;CELF-1 antibody;celf1 antibody;CELF1 CUGBP, Elav like family member 1 antibody;CELF1_HUMAN antibody;CUG BP and ETR 3 like factor 1 antibody;CUG BP antibody;CUG BP1 antibody;CUG RNA binding protein antibody;CUG triplet repeat RNA binding protein 1 antibody;CUG triplet repeat RNA-binding protein 1 antibody;CUG-BP antibody;CUG-BP- and ETR-3-like factor 1 antibody;CUG-BP1 antibody;CUGBP 1 antibody;CUGBP and ETR3 like factor 1 antibody;CUGBP antibody;CUGBP Elav like family member 1 antibody;CUGBP Elav-like family member 1 antibody;CUGBP1 antibody;Cytidine uridine guanosine binding protein 1 antibody;Deadenylation factor CUG BP antibody;Deadenylation factor CUG-BP antibody;Deadenylation factor CUGBP antibody;EDEN BP antibody;EDEN BP homolog antibody;EDEN-BP antibody;EDEN-BP homolog antibody;embryo deadenylation element binding protein antibody;embryo deadenylation element binding protein homolog antibody;Embryo deadenylation element-binding protein homolog antibody;hNab 50 antibody;hNab50 antibody;NAB 50 antibody;NAB50 antibody;NAPOR antibody;Nuclear polyadenylated RNA binding protein 50 kD antibody;Nuclear polyadenylated RNA binding protein antibody;RNA binding protein BRUNOL 2 antibody;RNA binding protein BRUNOL2 antibody;RNA-binding protein BRUNOL-2 antibody

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

CUG triplet repeat, RNA binding protein 1, also known as CUGBP1, is a protein which in humans is encoded by the CUGBP1 gene. Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms.