eIF5A Recombinant Rabbit Monoclonal Antibody [SC60-09] (ET1610-49)

UNIPROT #

P63241

PROTEIN NAME

eIF5A

SYNONYMS

eIF 4D antibody;eIF 5A 1 antibody;EIF 5A antibody;eIF 5A1 antibody;eIF-4D antibody;eIF-5A antibody;eIF-5A-1 antibody;eIF-5A1 antibody;eIF4D antibody;eif5a antibody;EIF5A1 antibody;eIF5AI antibody;Eukaryotic initiation factor 5A antibody;Eukaryotic initiation factor 5A isoform 1 antibody;Eukaryotic translation initiation factor 5A 1 antibody;Eukaryotic translation initiation factor 5A antibody;Eukaryotic translation initiation factor 5A-1 antibody;IF5A1_HUMAN antibody;MGC104255 antibody;MGC99547 antibody;Rev binding factor antibody;Rev-binding factor antibody;uORF A antibody;uORF antibody

SEQUENCE SIMILARITIES

Belongs to the eIF-5A family.

TISSUE SPECIFICITY

Expressed in umbilical vein endothelial cells and several cancer cell lines (at protein level).

POST-TRANSLATIONAL MODIFICATION

Acetylated. Deacetylated by SIRT2.; eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Endoplasmic reticulum membrane.

FUNCTION

In mammalian cells, translation is controlled at the level of polypeptide chain initiation by eukaryotic initiation factors. The human eukaryotic translation initiation factor 5A gene, also designated eIF-4D or eIF5A, maps to chromosome 17p13.1 and encodes a 154 amino acid protein that is linked to cellular polyamine homeostasis. eIF5A localizes to the nuclear and cytoplasmic compartments of mammalian cells where it can stimulate ribosomal peptidyl-transferase and may be involved in nucleocytoplasmic mRNA transport and/or protein translation. eIF5A contains a unique spermidine-derived post-translational modification at Lys-50, hypusine, which is necessary for eIF5A's biochemical activity and for cellular proliferative signaling. In addition, eIF5A is a cellular cofactor for the function of the Rev transactivator protein of human immunodeficiency virus type 1 (HIV-1). Inhibition of eIF5A interaction with Rev leads to a block of the viral replication cycle.