TRP1 Recombinant Rabbit Monoclonal Antibody [JU36-48] (ET7106-66)

UNIPROT #

P17643

PROTEIN NAME

TRP1

SYNONYMS

5 antibody;5,6 dihydroxyindole 2 carboxylic acid oxidase antibody;6-dihydroxyindole-2-carboxylic acid oxidase antibody;b-PROTEIN antibody;CAS2 antibody;Catalase B antibody;CATB antibody;DHICA oxidase antibody;Glycoprotein 75 antibody;GP75 antibody;Melanoma antigen gp75 antibody;OCA3 antibody;TRP antibody;TRP-1 antibody;TRP1 antibody;Tyrosinase related protein 1 antibody;Tyrosinase-related protein 1 antibody;TYRP antibody;TYRP1 antibody;TYRP1_HUMAN antibody;TYRRP antibody

SEQUENCE SIMILARITIES

Belongs to the tyrosinase family.

TISSUE SPECIFICITY

Pigment cells.

POST-TRANSLATIONAL MODIFICATION

Glycosylated.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

Tyrosinase (TYR), a type I membrane protein and copper-containing enzyme, is involved in the production of melanin, the primary pigment found in vertebrates. Melanin biogenesis requires the enzymatic activity of TYR, which catalyzes the critical and rate-limiting step of tyrosine hydroxylation in the biosynthesis of melanin. Defects effecting TYR activity result in various forms of albinism. The TYR-related proteins, TRP1 and TRP2, are also specifically expressed in melanocytes, and they likewise contribute to the synthesis of melanin within the melanosomes. The TRPs, including TYR, all share a similar transmembrane region, contain two metal-binding regions and a cysteine-rich epidermal growth factor motif, and are localized in the melanosomal membrane. These proteins, however, have distinct catalytic activity, and they individually contribute to the biosynthesis of melanin biopolymers. The TRPs are believed to exists as a multi-enzyme complex, as these proteins form aggregates together, and the expression of TRP1 also helps stabilize TYR in melanocytes.