IKZF3 Recombinant Rabbit Monoclonal Antibody [JE62-81] (HA720110)

UNIPROT #

Q9UKT9

PROTEIN NAME

IKZF3

SYNONYMS

AIO antibody;Aiolos antibody;IKAROS family zinc finger 3 (Aiolos) antibody;IKAROS family zinc finger 3 antibody;Ikaros family zinc finger protein 3 antibody;IKZF 3 antibody;IKZF3 antibody;IKZF3_HUMAN antibody;zinc finger DNA binding protein Aiolos antibody;Zinc finger protein Aiolos antibody;Zinc finger protein subfamily 1A 3 (Aiolos) antibody;Zinc finger protein subfamily 1A 3 antibody;Zinc finger protein subfamily 1A, member 3 antibody;ZNFN1A3 antibody

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

Zinc finger protein Aiolos also known as Ikaros family zinc finger protein 3 is a protein that in humans is encoded by the IKZF3 gene. This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants.