PAX5 Recombinant Rabbit Monoclonal Antibody [JJ08-87] (ET1701-49)

UNIPROT #

Q02548

PROTEIN NAME

PAX5

SYNONYMS

B cell lineage specific activator antibody;B cell lineage specific activator protein antibody;B cell specific activator protein antibody;B cell specific transcription factor antibody;B-cell-specific transcription factor antibody;BSAP antibody;EBB-1 antibody;KLP antibody;Paired box 5 antibody;Paired box gene 5 (B cell lineage specific activator protein) antibody;Paired box gene 5 (B cell lineage specific activator) antibody;Paired box gene 5 antibody;Paired box homeotic gene 5 antibody;Paired box protein Pax 5 antibody;Paired box protein Pax-5 antibody;Paired domain gene 5 antibody;PAX 5 antibody;PAX5 antibody;PAX5_HUMAN antibody;Transcription factor PAX 5 antibody

DEVELOPMENTAL STAGE

Expressed at early B-cell differentiation, in the developing CNS and in adult testis.

POST-TRANSLATIONAL MODIFICATION

O-glycosylated.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

The Pax family of nuclear transcription factors is comprised of nine members that function during embryogenesis to regulate the temporal and position-dependent differentiation of cells. Pax family genes are also involved in a variety of signal transduction pathways in the adult organism. Mutations in Pax proteins have been linked to disease and cancer in humans. For example, the human PAX5 gene encodes a B cell lineage-specific protein, Pax-5, also designated B cell specific activator protein or BSAP, which is expressed in pro-B, pre-B and mature B lymphocytes but not in plasma cells. Pax-5 functions to regulate not only B cell development, but also influences the balance between immunoglobulin secretion and B cell proliferation. Overexpression of Pax-5 has been implicated in cellular transformation, and in the case of small lymphocytic lymphomas with plasmacytoid differentiation, a t(9;14)(p13;q32) translocation resulting in the deregulation of PAX5 gene expression has been detected.