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IRF5 Recombinant Rabbit Monoclonal Antibody [SD203-07] (ET1612-15)

Price: Regular price $385.00

Volume

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Catalog# ET1612-15

Rabbit Monoclonal to IRF5

Tested for

  • WB

  • IF-Tissue

  • IHC-P

  • IP

Reacts with

  • Human

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free

Safety datasheet

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

IRF5 Recombinant Rabbit Monoclonal Antibody [SD203-07] (ET1612-15)

Immunogen

Recombinant protein within human irf5 aa 1-200.

Host

Rabbit

Positive Control

THP-1 cell lysate, U-937 cell lysate, A20 cell lysate, Rat spleen tissue lysate, mouse spleen tissue, rat spleen tissue, human spleen tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

SD203-07

RRID

AB_3070087

APPLICATION DILUTION

  • WB

  • 1:500-1:2,000

  • IF-Tissue

  • 1:50-1:200

  • IHC-P

  • 1:50-1:200

  • IP

  • Use at an assay dependent concentration.

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 56 kDa

Isotype

IgG

TARGET

UNIPROT #

Q13568

PROTEIN NAME

IRF5

SYNONYMS

Interferon regulatory factor 5 antibody;Interferon regulatory factor 5 bone marrow variant antibody;IRF 5 antibody;IRF-5 antibody;Irf5 antibody;IRF5_HUMAN antibody;SLEB10 antibody

SEQUENCE SIMILARITIES

Belongs to the IRF family.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation of serine and threonine residues in a C-terminal autoinhibitory region, stimulates dimerization, transport into the nucleus, assembly with the coactivator CBP/p300 and initiation of transcription.; 'Lys-63'-linked polyubiquitination by TRAF6 is required for activation.

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

Interferon regulatory factor 5 (IRF-5), belongs to the IRF family of DNA-binding factors, which includes IRF-1, IRF-2, IRF-3, IRF-4, IRF-6, IRF-7, ISGF-3γ p48 and IFN consensus sequence-binding protein (ICSBP). The IRF family regulate both interferon and interferon-inducible genes. IRF-5, like IRF-3 and IRF-7, is a direct transducer of virus-mediated signaling and plays a role in the expression of multiple cytokines/chemokines. Although IRF-5 is a direct target of p53, its cell cycle regulatory and proapoptotic effects are p53 independent.

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