RBX1 Rabbit Polyclonal Antibody (ER1802-9)

UNIPROT #

P62877

PROTEIN NAME

RBX1

SYNONYMS

BA554C12.1 antibody;E3 ubiquitin-protein ligase RBX1 antibody;FLJ60363 antibody;MGC13357 antibody;MGC1481 antibody;OTTHUMP00000028983 antibody;Protein ZYP antibody;Rbx 1 antibody;Rbx1 antibody;RBX1_HUMAN antibody;Regulator of cullins 1 antibody;Ring box 1 antibody;Ring box 1 E3 ubiquitin protein ligase antibody;RING box protein 1 antibody;RING finger protein 75 antibody;RING finger protein antibody;RING-box protein 1 antibody;Ringbox protein 1 antibody;RNF 75 antibody;RNF75 antibody;ROC 1 antibody;ZYP protein antibody

SEQUENCE SIMILARITIES

Belongs to the RING-box family.

TISSUE SPECIFICITY

Widely expressed.

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

Rbx1 (also designated ROC1 and Hrt1) and the closely related protein Rbx2 (also designated ROC2) are RING finger containing homologs of the yeast protein APC11, a member of the anaphase-promoting complex (APC). Rbx1 was shown to be a component of the von Hippel-Lindau (VHL) transcription elongation complex, which includes VHL, Elongin B, Elongin C and Cullin-2. Rbx1 interacts with Cullin-1 in the SCF (Skp1-Cdc53-F-box protein) ubiquitin ligase complex (2-4). Rbx1 functions as a common subunit of SCF complexes required for ubiquination of various proteins including yeast G1 cyclins, IkBa and b-catenin (2-4). Rbx1 was shown to enhance the ubiquitin ligase activity of the VHL/Cullin-2 complex, and of the SCF/Cullin-1 complex.