PSMD7 Rabbit Polyclonal Antibody (HA500354)

UNIPROT #

P51665

PROTEIN NAME

PSMD7

SYNONYMS

26S proteasome non ATPase regulatory subunit 7 antibody;26S proteasome non-ATPase regulatory subunit 7 antibody;26S proteasome regulatory subunit RPN8 antibody;26S proteasome regulatory subunit S12 antibody;integration site gene, mouse, homolog of antibody;Moloney leukemia virus 34 proviral antibody;Moloney leukemia virus 34 proviral integration antibody;MOV34 antibody;Mov34 homolog antibody;Mov34 protein homolog antibody;MOV34L antibody;P40 antibody;Proteasome (prosome, macropain) 26S subunit, non ATPase 7 antibody;Proteasome (prosome, macropain) 26S subunit, non ATPase, 7 (Mov34 homolog) antibody;Proteasome 26S S12 antibody;Proteasome 26S subunit, no-ATPase, 7 antibody;Proteasome subunit p40 antibody;PSD7_HUMAN antibody;PSMD 7 antibody;PSMD7 antibody;Rpn8 antibody;S12 antibody

SUBCELLULAR LOCATION

Cytosol, extracellular exosome, extracellular region, nucleoplasm, nucleus.

FUNCTION

26S proteasome non-ATPase regulatory subunit 7, also known as 26S proteasome non-ATPase subunit Rpn8, is an enzyme that in humans is encoded by the PSMD7 gene. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.