TNFAIP3 Rabbit Polyclonal Antibody (ER1706-32)

UNIPROT #

P21580

PROTEIN NAME

TNFAIP3

SYNONYMS

A20 antibody;AISBL antibody;MGC104522 antibody;MGC138687 antibody;MGC138688 antibody;OTU domain containing protein 7C antibody;OTU domain-containing protein 7C antibody;OTUD7C antibody;Putative DNA binding protein A20 antibody;Putative DNA-binding protein A20 antibody;TNAP3_HUMAN antibody;TNF alpha-induced protein 3 antibody;TNFA1P2 antibody;TNFAIP 3 antibody;TNFAIP3 (A20) antibody;TNFAIP3 antibody;Tumor necrosis factor alpha induced protein 3 antibody;Tumor necrosis factor alpha-induced protein 3 antibody;Tumor necrosis factor induced protein 3 antibody;Tumor necrosis factor inducible protein A20 antibody;tumor necrosis factor, alpha-induced protein 3 antibody;Zinc finger protein A20 antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase C64 family.

POST-TRANSLATIONAL MODIFICATION

Proteolytically cleaved by MALT1 upon TCR stimulation; disrupts NF-kappa-B inhibitory function and results in increased IL-2 production. It is proposed that only a fraction of TNFAIP3 colocalized with TCR and CBM complex is cleaved, leaving the main TNFAIP3 pool intact.

SUBCELLULAR LOCATION

Cytoplasm. Nucleus.

FUNCTION

A20 is a Cys2/Cys2 zinc finger protein that is induced by a variety of inflammatory stimuli and regulates gene expression. Specifically, A20 is induced by tumor necrosis factor (TNF) and interleukin 1 (IL-1), and acts as a negative regulator of nuclear factor κ B (NFκB) gene expression. By inhibiting NFκB activation, A20 plays a critical role in terminating NFκB responses to various stimuli. Although the C-terminal region of A20 contains seven zinc finger domains, only four of these domains are required for in vitro inhibition of TNF-induced NFκB activation. A20 also interacts with several other proteins, such as TRAF2, TRAF6 and IkB kinase (IKK) γ protein, and can thereby inhibit cell death. TXBP151, a novel A20-binding protein, may mediate the anti-apoptotic activity of A20. Involved in the negative feedback regulation of signal transduction, A20 and A20-binding proteins may be useful as novel therapeutic tools in the treatment of a variety of diseases.