UBC9 Recombinant Rabbit Monoclonal Antibody [SC0534] (ET1610-21)

UNIPROT #

P63279

PROTEIN NAME

UBC9

SYNONYMS

C358B7.1 antibody;p18 antibody;SUMO 1 protein ligase antibody;SUMO conjugating enzyme UBC9 antibody;SUMO-conjugating enzyme UBC9 antibody;SUMO-protein ligase antibody;SUMO1 protein ligase antibody;UBC9 antibody;UBC9_HUMAN antibody;UBCE9 antibody;Ube2i antibody;Ubiquitin carrier protein 9 antibody;Ubiquitin carrier protein antibody;Ubiquitin carrier protein I antibody;Ubiquitin conjugating enzyme 9 antibody;Ubiquitin conjugating enzyme E2I (homologous to yeast UBC9) antibody;Ubiquitin conjugating enzyme E2I (UBC9 homolog, yeast) antibody;Ubiquitin conjugating enzyme UbcE2A antibody;Ubiquitin like protein SUMO 1 conjugating enzyme antibody;Ubiquitin protein ligase E2I antibody;Ubiquitin-conjugating enzyme E2 I antibody;Ubiquitin-protein ligase I antibody

SEQUENCE SIMILARITIES

Belongs to the ubiquitin-conjugating enzyme family.

TISSUE SPECIFICITY

Expressed in heart, skeletal muscle, pancreas, kidney, liver, lung, placenta and brain. Also expressed in testis and thymus.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation at Ser-71 significantly enhances SUMOylation activity.

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

UBC9 is a component of the ubiquitin-mediated proteolytic pathway, which targets proteins for degradation by the 26S proteasome, mediates endocytosis and directs protein subcellular localization. Ub and Ub-like molecules are systematically transferred from E2 conjugating enzymes to the targeted substrate by way of an E3 ubiquitin ligase. UBC9 functions as an E2 ubiquitin conjugating enzyme that preferentially associates with the ubiquitin homolog designated SUMO-1 or sentrin, a component of the sentrinization complex. Characteristic of the E2 family members, UBC9 contains a conserved cysteine residue that is required for the thio ester formation between Ub-like proteins and the E2 member, and it shares a conserved UBC domain. Substrates for UBC9 include transcription factors E12 and E47 and mitotic regulators RanBP2 and RanGAP1, which indicates that UBC9 may regulate various cellular processes including cell cycle progression and differentiation.