USP10 Recombinant Rabbit Monoclonal Antibody [JU32-62] (ET1706-12)

UNIPROT #

Q14694

PROTEIN NAME

USP10

SYNONYMS

Deubiquitinating enzyme 10 antibody;KIAA0190 antibody;MGC124997 antibody;MGC2621 antibody;Ubiquitin carboxyl terminal hydrolase 10 antibody;Ubiquitin carboxyl-terminal hydrolase 10 antibody;Ubiquitin specific peptidase 10 antibody;Ubiquitin specific processing protease 10 antibody;Ubiquitin specific protease 10 antibody;Ubiquitin thioesterase 10 antibody;Ubiquitin thiolesterase 10 antibody;Ubiquitin-specific-processing protease 10 antibody;UBP10_HUMAN antibody;UBPO antibody;USP 10 antibody;USP10 antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase C19 family. USP10 subfamily.

TISSUE SPECIFICITY

Widely expressed.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by ATM following DNA damage, leading to stablization and translocation it to the nucleus.; Ubiquitinated. Deubiquitinated by USP13.

SUBCELLULAR LOCATION

Cytoplasm. Nucleus.

FUNCTION

The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. Through the use of a wide range of enzymes that can add or remove ubiquitin, the Ub pathway controls many intracellular processes such as signal transduction, transcriptional activation and cell cycle progression. USP10 (ubiquitin specific peptidase 10), also known as UBPO, is a 798 amino acid protein that belongs to the ubiquitin-specific protease family of cysteine proteases. Expressed in a variety of tissues, USP10 functions to catalyze the cleavage of ubiquitin from ubiquitin-conjugated protein substrates, possibly playing a role in the activity of the DNA-bound androgen receptor complex.