Human CD4 Recombinant Mouse Monoclonal Antibody [PSH04-93] (HA601338)

UNIPROT #

P01730

PROTEIN NAME

Human CD4

SYNONYMS

CD 4 antibody;CD4 (L3T4) antibody;CD4 antibody;CD4 antigen (p55) antibody;CD4 antigen antibody;CD4 molecule antibody;CD4 receptor antibody;CD4+ Lymphocyte deficiency, included antibody;CD4_HUMAN antibody;CD4mut antibody;L3T4 antibody;Leu3 antibody;Ly-4 antibody;Lymphocyte antigen CD4 antibody;MGC165891 antibody;OTTHUMP00000238897 antibody;p55 antibody;T cell antigen T4 antibody;T cell antigen T4/LEU3 antibody;T cell differentiation antigen L3T4 antibody;T cell OKT4 deficiency, included antibody;T cell surface antigen T4/Leu 3 antibody;T cell surface antigen T4/Leu3 antibody;T cell surface glycoprotein CD4 antibody;T-cell surface antigen T4/Leu-3 antibody;T-cell surface glycoprotein CD4 antibody;W3/25 antibody;W3/25 antigen antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

In molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). CD4 is found on the surface of immune cells such as helper T cells, monocytes, macrophages, and dendritic cells. It was discovered in the late 1970s and was originally known as leu-3 and T4 (after the OKT4 monoclonal antibody that reacted with it) before being named CD4 in 1984. In humans, the CD4 protein is encoded by the CD4 gene. CD4+ T helper cells are white blood cells that are an essential part of the human immune system. They are often referred to as CD4 cells, T-helper cells or T4 cells. They are called helper cells because one of their main roles is to send signals to other types of immune cells, including CD8 killer cells, which then destroy the infectious particle. If CD4 cells become depleted, for example in untreated HIV infection, or following immune suppression prior to a transplant, the body is left vulnerable to a wide range of infections that it would otherwise have been able to fight.