Caveolin-1 Recombinant Rabbit Monoclonal Antibody [SZ02-01] (ET1603-1)

UNIPROT #

Q03135

PROTEIN NAME

Caveolin-1

SYNONYMS

BSCL3 antibody;CAV antibody;CAV1 antibody;CAV1_HUMAN antibody;caveolae protein, 22 kD antibody;caveolin 1 alpha isoform antibody;caveolin 1 beta isoform antibody;Caveolin 1 caveolae protein 22kDa antibody;Caveolin-1 antibody;Caveolin1 antibody;cell growth-inhibiting protein 32 antibody;CGL3 antibody;LCCNS antibody;MSTP085 antibody;OTTHUMP00000025031 antibody;PPH3 antibody;VIP 21 antibody;VIP21 antibody

SEQUENCE SIMILARITIES

Belongs to the caveolin family.

TISSUE SPECIFICITY

Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Expressed in the brain.

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination. Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation.; The initiator methionine for isoform 2 is removed during or just after translation. The new N-terminal amino acid is then N-acetylated.; Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.

SUBCELLULAR LOCATION

Golgi apparatus membrane, Cell membrane, Membrane.

FUNCTION

Caveolae (also known as plasmalemmal vesicles) are 50-100 nM flask-shaped membranes that represent a subcompartment of the plasma membrane. On the basis of morphological studies, caveolae have been implicated to function in the transcytosis of various macromolecules (including LDL) across capillary endothelial cells, uptake of small molecules via potocytosis and the compartmentalization of certain signaling molecules including G protein-coupled receptors. Three proteins, caveolin-1, caveolin-2 and caveolin-3, have been identified as principal components of caveolae. Two forms of caveolin-1, designated alpha and beta, share a distinct but overlapping cellular distribution and differ by an amino terminal 31 amino acid sequence which is absent from the beta isoform. Caveolin-1 shares 31% identity with caveolin-2 and 65% identity with caveolin-3 at the amino acid level. Functionally, the three proteins differ in their interactions with heterotrimeric G protein isoforms.