SOX11 Recombinant Rabbit Monoclonal Antibody [SD203-08] (ET1612-76)

UNIPROT #

P35716

PROTEIN NAME

SOX11

SYNONYMS

MRD27 antibody;SOX11 antibody;SOX11_HUMAN antibody;SRY (sex determining region Y) box 11 antibody;SRY related HMG box gene 11 antibody;SRY-box 11 antibody;Transcription factor SOX-11 antibody

TISSUE SPECIFICITY

Expressed primarily in the brain and heart, with low expression in the kidney, pancreas and muscle.

DEVELOPMENTAL STAGE

Expressed primarily in the fetal brain, with low expression in the lung, and kidney at 6-7 weeks dpc. Weak expression in the fetal heart and muscle.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

The Sox family are comprised of members that are related to the mammalian sex determining gene SRY. The Sox family of genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been conserved during evolution and play key roles during animal development. Some are involved in human diseases, including sex reversal. Sox-11 (SRY (sex determining region Y)-box 11) is a 441 amino acid nuclear protein expressed mainly in the nervous system. Containing an HMG box DNA-binding domain, Sox-11 may play a critical role in the developing nervous system.