PGP9.5 Recombinant Rabbit Monoclonal Antibody [JM10-59] (ET1703-22)

UNIPROT #

P09936

PROTEIN NAME

PGP9.5

SYNONYMS

Epididymis luminal protein 117 antibody;Epididymis secretory protein Li 53 antibody;HEL 117 antibody;HEL S 53 antibody;NDGOA antibody;Neuron cytoplasmic protein 9.5 antibody;OTTHUMP00000218137 antibody;OTTHUMP00000218139 antibody;OTTHUMP00000218140 antibody;OTTHUMP00000218141 antibody;Park 5 antibody;PARK5 antibody;PGP 9.5 antibody;PGP9.5 antibody;PGP95 antibody;Protein gene product 9.5 antibody;Ubiquitin C terminal esterase L1 antibody;Ubiquitin C terminal hydrolase antibody;Ubiquitin C terminal hydrolase L1 antibody;Ubiquitin carboxyl terminal esterase L1 antibody;Ubiquitin carboxyl terminal hydrolase isozyme L1 antibody;Ubiquitin carboxyl-terminal hydrolase isozyme L1 antibody;Ubiquitin thioesterase L1 antibody;Ubiquitin thiolesterase antibody;Ubiquitin thiolesterase L1 antibody;UCH-L1 antibody;UCHL1 antibody;UCHL1_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase C12 family.

TISSUE SPECIFICITY

Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients.

POST-TRANSLATIONAL MODIFICATION

O-glycosylated.

SUBCELLULAR LOCATION

Cytoplasm, Endoplasmic reticulum membrane.

FUNCTION

UCH-L1 (ubiquitin C-terminal hydrolase) is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. Expression of UCH-L1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. UCH-L1 is expressed in brain neurons. Examination of specific brain regions reveals expression in all areas tested, particularly in the substantia nigra. UCH-L1 represents 1-2% of total soluble brain protein. Its occurrence in Lewy bodies and its function in the proteasome pathway make it a compelling candidate gene in Parkinson disease. The gene which encodes UCH-L1 maps to human chromosome 4p13. The 230 amino acid human UCH-L3 protein is 54% identical to that of UCH-L1. UCH-L3 is the predominant thiol protease and has high-affinity binding sites for ubiquitin.