Flt3 Rabbit Polyclonal Antibody (ER2001-25)

UNIPROT #

P36888

PROTEIN NAME

Flt3

SYNONYMS

CD 135 antibody;CD135 antibody;CD135 antigen antibody;Fetal liver kinase 2 antibody;FL cytokine receptor antibody;Flk 2 antibody;Flk2 antibody;Flt 3 antibody;FLT-3 antibody;Flt3 antibody;FLT3_HUMAN antibody;FMS like tyrosine kinase 3 antibody;Fms related tyrosine kinase 3 antibody;Fms-like tyrosine kinase 3 antibody;Growth factor receptor tyrosine kinase type III antibody;Ly-72 antibody;OTTHUMP0000004234 antibody;Receptor type tyrosine protein kinase FLT3 antibody;Stem cell tyrosine kinase 1 antibody;Stk 1 antibody;STK-1 antibody;Stk1 antibody;Tyrosine protein kinase receptor FLT3 antibody;Tyrosine-protein kinase receptor FLT3 antibody

SUBCELLULAR LOCATION

Endoplasmic reticulum lumen, membrane.

FUNCTION

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.