LY75 Recombinant Rabbit Monoclonal Antibody [JB87-35] (ET7107-58)

UNIPROT #

O60449

PROTEIN NAME

LY75

SYNONYMS

C-type lectin domain family 13 member B antibody;CD 205 antibody;CD205 antibody;CD205 antigen antibody;CLEC 13B antibody;CLEC13B antibody;DEC 205 antibody;DEC-205 antibody;DEC205 antibody;gp200 antibody;gp200 MR6 antibody;gp200-MR6 antibody;LY 75 antibody;Ly-75 antibody;LY75 antibody;LY75_HUMAN antibody;Lymphocyte antigen 75 antibody;Renal Cell Carcinoma (gp200) antibody

TISSUE SPECIFICITY

Expressed in spleen, thymus, colon and peripheral blood lymphocytes. Detected in myeloid and B-lymphoid cell lines. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.

POST-TRANSLATIONAL MODIFICATION

N-glycosylated.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

DEC-205 (LY75, lymphocyte antigen 75, GP200-MR6) is a 1,695 residue (mature form) multilectin receptor that belongs to the MMR (macrophage mannose receptor) family of multidomain molecules. MMR family molecules mediate membrane receptor targeting to endosomes or lysosomes rich in major histocompatibility complex class II (MHC II) products. Expressed in mature dendritic cells (DC), DEC-205 contains an extracellular N-terminal cysteine-rich domain, a fibronectin type II domain, ten C-type carbohydrate recognition domains, a single transmembrane region and a small cytoplasmic C-terminal domain (31 amino acids) containing a tyrosine at 1679. DEC-205 elicits either an agonistic or antagonistic effect on IL-4 function, which is demonstrated by the ability of DEC-205 to imitate IL-4-induced maturation of epithelium or to inhibit IL-4-induced proliferation of T cells, respectively.