MHC class I Recombinant Rabbit Monoclonal Antibody [JF10-38] (ET1702-47)

UNIPROT #

P04439

PROTEIN NAME

MHC class I

SYNONYMS

A 28 antibody;A 9 antibody;Antigen presenting molecule antibody;Aw 24 antibody;Aw 68 antibody;CLASS I HISTOCOMPATIBILITY ANTIGEN antibody;H2 K1 antibody;H2K antibody;HLA A antibody;HLA class I histocompatibility antigen A 1 alpha chain antibody;HLA class I histocompatibility antigen A 11 alpha chain antibody;HLA class I histocompatibility antigen A 2 alpha chain antibody;HLA class I histocompatibility antigen A 24 alpha chain antibody;HLA class I histocompatibility antigen A 3 alpha chain antibody;HLA class I histocompatibility antigen A 30 alpha chain antibody;HLA class I histocompatibility antigen A 32 alpha chain antibody;HLA class I histocompatibility antigen A 68 alpha chain antibody;HLAA antibody;Leukocyte antigen class I A antibody;Major histocompatibility complex class I A antibody;MHC class I antigen A 1 antibody;MHC class I antigen A*11 antibody;MHC class I antigen A*2 antibody;MHC class I antigen A*24 antibody;MHC class I antigen A*3 antibody;MHC class I antigen A*30 antibody;MHC class I antigen A*32 antibody;MHC class I antigen A*68 antibody;MHC class I antigen HLA A heavy chain antibody;MHC class I heavy chain H2 K antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Major histocompatibility complex (MHC) molecules, also designated human leukocyte antigen (HLA) molecules, are cell-surface receptors that bind foreign peptides and present them to T lymphocytes. MHC class I molecules consist of two polypeptide chains, an a or heavy chain, and β-2-Microglobulin, a non-covalently associated protein. Cytotoxic T lymphocytes bind antigenic peptides presented by MHC class I molecules. Antigens that bind to MHC class I molecules are typically 8-10 residues in length and are stabilized in a peptide binding groove. MHC class II molecules are encoded by polymorphic MHC genes and consist of a non-covalent complex of an a and b chain. Helper T lymphocytes bind antigenic peptides presented by MHC class II molecules. MHC class II molecules bind 13-18 amino acid antigenic peptides. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM and -DO molecules regulate binding of exogenous peptides to class II molecules (HLA-DR) by sustaining a conformation that favors peptide exchange. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes.