B7-H4(VTCN1) Rabbit Polyclonal Antibody (R1512-1)

UNIPROT #

Q7Z7D3

PROTEIN NAME

B7-H4(VTCN1)

SYNONYMS

B7 family member, H4 antibody;B7 H4 antibody;B7 homolog 4 antibody;B7 superfamily member 1 antibody;B7 superfamily, member 1 antibody;B7-H4 antibody;B7h.5 antibody;B7h4 antibody;B7S1 antibody;B7x antibody;BC032925 antibody;Immune costimulatory protein B7-H4 antibody;Immune costimulatory protein B7H4 antibody;MGC41287 antibody;PRO1291 antibody;Protein B7S1 antibody;RP11 229A19.4 antibody;T cell costimulatory molecule B7x antibody;T-cell costimulatory molecule B7x antibody;V set domain-containing T cell activation inhibitor 1 antibody;V-set domain-containing T-cell activation inhibitor 1 antibody;VCTN1 antibody;Vtcn1 antibody;VTCN1_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the immunoglobulin superfamily. BTN/MOG family.

TISSUE SPECIFICITY

Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis.

POST-TRANSLATIONAL MODIFICATION

N-glycosylated.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory proteins. One such protein, B7-H4 (B7-homolog 4, also designated VTCN1), belongs to the B7 Immunoglobulin superfamily of ligand-lymphocyte interacting proteins. Expressed primarily on the membrane of lymphoid cells, B7-H4 is an immunoinhibitory protein that interacts with receptors on the surface of T lymphocytes, thus mediating cellular and humoral immune responses. Overexpression of the B7-H4 protein is associated with certain malignancies, including ovarian and breast cancer, as its interaction with T cells supresses tumor-associated immunity. Current research suggests that, similar to Mucin 16 (CA125), B7-H4 may be a useful biomarker for the early detection of ovarian cancer.