CD3 Recombinant Mouse Monoclonal Antibody [PD01-43] (HA601110)

UNIPROT #

P07766

PROTEIN NAME

CD3

SYNONYMS

4930549J05Rik antibody;A430104F18Rik antibody;AW552088 antibody;Cd247 antibody;CD247 antigen antibody;CD247 antigen, zeta subunit antibody;CD247 molecule antibody;CD3 antibody;CD3 antigen, delta subunit antibody;CD3 delta antibody;CD3 epsilon antibody;CD3 eta antibody;CD3 gamma antibody;CD3 molecule delta polypeptide antibody;CD3 molecule, epsilon polypeptide antibody;CD3 molecule, gamma polypeptide antibody;CD3 zeta antibody;CD3-DELTA antibody;CD3d antibody;CD3D antigen delta polypeptide antibody;CD3d antigen, delta polypeptide (TiT3 complex) antibody;CD3d molecule delta antibody;CD3d molecule delta CD3 TCR complex antibody;CD3d molecule, delta (CD3-TCR complex) antibody;CD3D_HUMAN antibody;CD3E antibody;CD3e antigen antibody;CD3E antigen epsilon polypeptide antibody;CD3e antigen, epsilon polypeptide (TiT3 complex) antibody;CD3e molecule epsilon antibody;CD3e molecule epsilon CD3 TCR complex antibody;CD3e molecule, epsilon (CD3-TCR complex) antibody;CD3epsilon antibody;CD3G antibody;CD3g antigen antibody;CD3G antigen gamma polypeptide antibody;CD3g antigen, gamma polypeptide (TiT3 complex) antibody;CD3g molecule gamma antibody;CD3g molecule gamma CD3 TCR complex antibody;CD3g molecule, gamma (CD3-TCR complex) antibody;CD3H antibody;CD3Q antibody;CD3Z antibody;CD3zeta antibody;Ctg3 antibody;FLJ17620 antibody;FLJ17664 antibody;FLJ18683 antibody;FLJ79544 antibody;FLJ94613 antibody;IMD19 antibody;Leu-4 antibody;MGC138597 antibody;OKT3, delta chain antibody;OTTHUMP00000032544 antibody;T cell receptor antibody;T cell receptor T3 delta chain antibody;T cell receptor T3 gamma chain antibody;T cell receptor T3 zeta chain antibody;T cell receptor zeta chain antibody;T cell surface antigen T3/Leu 4 epsilon chain antibody;T cell surface glycoprotein CD3 antibody;T cell surface glycoprotein CD3 delta chain antibody;T cell surface glycoprotein CD3 epsilon chain antibody;T cell surface glycoprotein CD3 gamma chain antibody;T cell surface glycoprotein CD3 zeta chain antibody;T-cell antigen receptor complex, delta subunit of T3 antibody;T-cell antigen receptor complex, epsilon subunit of T3 antibody;T-cell antigen receptor complex, gamma subunit of T3 antibody;T-cell antigen receptor complex, zeta subunit of CD3 antibody;T-cell receptor T3 delta chain antibody;T-cell receptor T3 gamma chain antibody;T-cell surface antigen T3/Leu-4 epsilon chain antibody;T-cell surface glycoprotein CD3 delta chain antibody;T-cell surface glycoprotein CD3 epsilon chain antibody;T-cell surface glycoprotein CD3 gamma chain antibody;T3 antibody;T3d antibody;T3e antibody;T3g antibody;T3z antibody;TCRE antibody;TCRk antibody;Tcrz antibody;TCRzeta antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

The CD3 protein is a T-cell marker, a complex of four structurally distinct membrane glycoprotein isoforms, 20-50 kDa, comprising extracellular, transmembrane and intracellular domains. The CD3 complex is responsible for mediating signal transduction to the internal environment upon antigenic recognition by TCR, causing T-cell proliferation and release of cytokines. Except for a weak expression in Purkinje cells (with some of the Abs) and activated NK-cells, CD3 is found only in T-cells. CD3 appear in the cytoplasm of prothymocytes, and on the surface of about 95% of thymocytes, while cytoplasmic CD3 is lost as the cells differentiate into medullary thymocytes. In therapy resistant celiac disease, a shift from membranous to cytoplasmic CD3 expression is seen (together with loss of CD8). In malignant lymphomas, CD3 is a pan-T-cell lineage-restricted antigen, detected in 80-97% of the T-cell lymphomas. Mature T-cell lymphomas including cases of mycosis fungoides, peripheral T-cell lymphoma and anaplastic large cell lymphoma may aberrantly lose CD3. NK-cell lymphomas can show a cytoplasmic reaction. Reed-Sternberg cells may show a globular paranuclear reaction. CD3 is an important marker in the classification of malignant lymphomas and lymphoid leukaemias. Also the marker is useful for the identification of T-cells in, e.g., celiac disease, lymphocytic colitis and colorectal carcinomas associated with loss of a mismatch repair protein.