CD8 alpha Recombinant Rabbit Monoclonal Antibody [SI18-01] (ET1606-31)

UNIPROT #

P01732

PROTEIN NAME

CD8 alpha

SYNONYMS

alpha polypeptide (p32) antibody;CD8 antibody;CD8 antigen alpha polypeptide antibody;CD8 antigen alpha polypeptide (p32) antibody;CD8a antibody;CD8A antigen antibody;CD8A molecule antibody;CD8A_HUMAN antibody;Leu2 antibody;Leu2 T lymphocyte antigen antibody;Ly3 antibody;LYT3 antibody;MAL antibody;OKT8 T cell antigen antibody;OTTHUMP00000160760 antibody;OTTHUMP00000160764 antibody;OTTHUMP00000203528 antibody;OTTHUMP00000203721 antibody;p32 antibody;T cell antigen Leu2 antibody;T cell co receptor antibody;T-cell surface glycoprotein CD8 alpha chain antibody;T-lymphocyte differentiation antigen T8/Leu-2 antibody;T8 T cell antigen antibody;T8/Leu-2 T-lymphocyte differentiation antigen antibody

TISSUE SPECIFICITY

CD8 on thymus-derived T-cells usually consists of a disulfide-linked alpha/CD8A and a beta/CD8B chain. Less frequently, CD8 can be expressed as a CD8A homodimer. A subset of natural killer cells, memory T-cells, intraepithelial lymphocytes, monocytes and dendritic cells expresses CD8A homodimers. Expressed at the cell surface of plasmacytoid dendritic cells upon herpes simplex virus-1 stimulation.

POST-TRANSLATIONAL MODIFICATION

Palmitoylated, but association with CD8B seems to be more important for the enrichment of CD8A in lipid rafts.; O-glycosylated.; Phosphorylated in cytotoxic T-lymphocytes (CTLs) following activation.

SUBCELLULAR LOCATION

Cell membrane, Secreted.

FUNCTION

The T cell receptor (TCR) is a heterodimer composed of either α and β or γ and δ chains. CD3 chains and the CD4 or CD8 (CD8-α and CD8-β) co-receptors are also required for efficient signal transduction through the TCR. The TCR is expressed on T helper and T cytotoxic cells that can be distinguished by their expression of CD4 and CD8 proteins; T helper cells express CD4 proteins and T cytotoxic cells display CD8 proteins. CD8s are cell surface glycoproteins that exist as two chain complex (αα or αβ) receptors that bind class I MHC molecules presented by the antigen-presenting cell (APC). A primary function of CD8 proteins is to facilitate antigen recognition by the TCR and to strengthen the avidity of the TCR-antigen interactions. An additional role for CD8-expressing T cells may be to maintain low levels of HIV expression.