Interferon gamma Recombinant Rabbit Monoclonal Antibody [JM10-10] (ET1703-17)

UNIPROT #

P01579

PROTEIN NAME

Interferon gamma

SYNONYMS

IFG antibody;IFI antibody;IFN gamma antibody;IFN, immune antibody;IFN-gamma antibody;IFNG antibody;IFNG_HUMAN antibody;Immune interferon antibody;Interferon gamma antibody

SEQUENCE SIMILARITIES

Belongs to the type II (or gamma) interferon family.

TISSUE SPECIFICITY

Released primarily from activated T lymphocytes.

POST-TRANSLATIONAL MODIFICATION

Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Interferon gamma (IFN-γ) is a dimerized soluble cytokine that is the only member of the type II class of interferons. In humans, the IFN-γ protein is encoded by the IFNG gene. IFN-γ, or type II interferon, is a cytokine that is critical for innate and adaptive immunity against viral, some bacterial and protozoan infections. IFN-γ is an important activator of macrophages and inducer of major histocompatibility complex class II molecule expression. Aberrant IFN-γ expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFN-γ in the immune system stems in part from its ability to inhibit viral replication directly, and most importantly from its immunostimulatory and immunomodulatory effects. IFN-γ is produced predominantly by natural killer cells (NK) and natural killer T cells (NKT) as part of the innate immune response, and by CD4 Th1 and CD8 cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops as part of the adaptive immune response. IFN-γ is also produced by non-cytotoxic innate lymphoid cells (ILC), a family of immune cells first discovered in the early 2010s.