RANKL Rabbit Polyclonal Antibody (HA500369)

UNIPROT #

O14788

PROTEIN NAME

RANKL

SYNONYMS

CD254 antibody;hRANKL2 antibody;ODF antibody;OPGL antibody;OPTB2 antibody;Osteoclast differentiation factor antibody;Osteoprotegerin ligand antibody;Rank Ligand antibody;RANKL antibody;Receptor activator of nuclear factor kappa B ligand antibody;Receptor activator of nuclear factor kappa-B ligand antibody;sOdf antibody;TNF related activation induced cytokine antibody;TNF-related activation-induced cytokine antibody;TNF11_HUMAN antibody;TNFSF 11 antibody;Tnfsf11 antibody;TRANCE antibody;Tumor necrosis factor (ligand) superfamily member 11 antibody;Tumor necrosis factor ligand superfamily member 11 antibody;Tumor necrosis factor ligand superfamily member 11, soluble form antibody

SUBCELLULAR LOCATION

Cell membrane, Cytoplasm.

FUNCTION

Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation.