CD3G Recombinant Rabbit Monoclonal Antibody [JB38-29] (ET7107-55)

UNIPROT #

P09693

PROTEIN NAME

CD3G

SYNONYMS

CD3 gamma antibody;CD3-GAMMA antibody;CD3g antibody;CD3g antigen gamma polypeptide (TiT3 complex) antibody;CD3g antigen gamma polypeptide antibody;CD3g molecule gamma (CD3 TCR complex) antibody;CD3g molecule gamma antibody;CD3G_HUMAN antibody;FLJ17620 antibody;FLJ17664 antibody;FLJ79544 antibody;FLJ94613 antibody;MGC138597 antibody;T cell antigen receptor complex gamma subunit of T3 antibody;T-cell receptor T3 gamma chain antibody;T-cell surface glycoprotein CD3 gamma chain antibody;T3G antibody

POST-TRANSLATIONAL MODIFICATION

Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8. Phosphorylated also by PKC; leading to the TCR complex down-regulation.; Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

The T cell antigen receptor (TCR) recognizes foreign antigens and translates such recognition events into intracellular signals that elicit a change in the cell from a dormant to an activated state. Much of this signaling process can be attributed to a multisubunit complex of proteins that associates directly with the TCR. This complex has been designated CD3 (cluster of differentiation 3). It is composed of five invariant polypeptide chains that associate to form three dimers: a heterodimer of gamma and epsilon chains (γε), a heterodimer of delta and epsilon chains (δε) and a homodimer of two zeta chains (ζζ) or a heterodimer of zeta and eta chains (ζη). The ζ and η chains are encoded by the same gene but differ in their carboxyl-terminal ends due to an alternative splicing event. The γ, ε and δ chains each contain a single copy of a conserved immunoreceptor tyrosine-based activation motif (ITAM).