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CD19 Recombinant Rabbit Monoclonal Antibody [JF100-06] (ET1702-93)

Price: Regular price $385.00

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Catalog# ET1702-93

Rabbit Monoclonal to CD19

Tested for

  • WB

  • IF-Cell

  • IF-Tissue

  • IHC-P

  • FC

  • mIHC

Reacts with

  • Human

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
This product has been cited in peer reviewed publications, see list HERE

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

CD19 Recombinant Rabbit Monoclonal Antibody [JF100-06] (ET1702-93)

Immunogen

Recombinant protein within human cd19 aa 294-556 / 556.

Host

Rabbit

Positive Control

Raji cell lysate, Ramos cell lysate, Daudi cell lysate, Raji, human spleen tissue, Daudi, human tonsils tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JF100-06

RRID

AB_3070352

APPLICATION DILUTION

  • WB

  • 1:10,000

  • IF-Cell

  • 1:50

  • IHC-P

  • 1:1,000

  • IF-Tissue

  • 1:200

  • FC

  • 1:1,000

  • mIHC

  • 1:500

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 61 kDa

Isotype

IgG

TARGET

UNIPROT #

P15391

PROTEIN NAME

CD19

SYNONYMS

antibody;deficiency due to defect in CD19, included antibody;AW495831 antibody;B lymphocyte antigen CD19 antibody;B lymphocyte surface antigen B4 antibody;B-lymphocyte antigen CD19 antibody;B-lymphocyte surface antigen B4 antibody;B4 antibody;CD19 antibody;CD19 antigen antibody;CD19 molecule antibody;Cd19 protein antibody;CD19_HUMAN antibody;CVID3 antibody;Differentiation antigen CD19 antibody;Leu 12 antibody;Leu-12 antibody;Leu12 antibody;MGC109570 antibody;MGC12802 antibody;T-cell surface antigen Leu-12 antibody

TISSUE SPECIFICITY

Detected on marginal zone and germinal center B cells in lymph nodes. Detected on blood B cells (at protein level).

POST-TRANSLATIONAL MODIFICATION

Phosphorylated on tyrosine following B-cell activation. Phosphorylated on tyrosine residues by LYN. Tyrosine residues are phosphorylated sequentially after activation of the B cell receptor. Phosphorylation of Tyr-531 is extremely rapid, followed by phosphorylation at Tyr-409. In contrast, phosphorylation of Tyr-500 appears more slowly and is more transient, returning rapidly to basal levels (By similarity).

SUBCELLULAR LOCATION

Membrane.

FUNCTION

B-lymphocyte antigen CD19, also known as CD19 molecule (Cluster of Differentiation 19), B-Lymphocyte Surface Antigen B4, T-Cell Surface Antigen Leu-12 and CVID3 is a transmembrane protein that in humans is encoded by the gene CD19. In humans, CD19 is expressed in all B lineage cells. Contrary to some early doubts, human plasma cells do express CD19, as confirmed by others. CD19 plays two major roles in human B cells: on the one hand, it acts as an adaptor protein to recruit cytoplasmic signaling proteins to the membrane; on the other, it works within the CD19/CD21 complex to decrease the threshold for B cell receptor signaling pathways. Due to its presence on all B cells, it is a biomarker for B lymphocyte development, lymphoma diagnosis and can be utilized as a target for leukemia immunotherapies.

CITATIONS

  • Che, L. H., Liu, J. W., Huo, J. P., Luo, R., Xu, R. M., He, C., Li, Y. Q., Zhou, A. J., Huang, P., Chen, Y. Y., Ni, W., Zhou, Y. X., Liu, Y. Y., Li, H. Y., Zhou, R., Mo, H., & Li, J. M.

    A single-cell atlas of liver metastases of colorectal cancer reveals reprogramming of the tumor microenvironment in response to preoperative chemotherapy

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