CD26 Recombinant Rabbit Monoclonal Antibody [JM11-42] (ET1703-93)

UNIPROT #

P27487

PROTEIN NAME

CD26

SYNONYMS

CD26 antigen antibody;ADA-binding protein antibody;ADABP antibody;ADCP 2 antibody;ADCP-2 antibody;ADCP2 antibody;Adenosine deaminase complexing protein 2 antibody;CD 26 antibody;CD26 antibody;CD26 antigen 3 antibody;Dipeptidyl peptidase 4 antibody;Dipeptidyl peptidase 4 soluble form antibody;Dipeptidyl peptidase IV antibody;Dipeptidyl peptidase IV membrane form antibody;Dipeptidyl peptidase IV soluble form antibody;Dipeptidyl peptidase, intestinal antibody;Dipeptidylpeptidase 4 antibody;Dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2) antibody;Dipeptidylpeptidase IV antibody;DPP 4 antibody;DPP IV antibody;DPP IV estoenzyme antibody;DPP4 antibody;DPP4_HUMAN antibody;DPPIV antibody;Intestinal dipeptidyl peptidase antibody;T cell activation antigen CD26 antibody;T-cell activation antigen CD26 antibody;TP 103 antibody;TP103 antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase S9B family. DPPIV subfamily.

TISSUE SPECIFICITY

Expressed specifically in lymphatic vessels but not in blood vessels in the skin, small intestine, esophagus, ovary, breast and prostate glands. Not detected in lymphatic vessels in the lung, kidney, uterus, liver and stomach (at protein level). Expressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon.

POST-TRANSLATIONAL MODIFICATION

The soluble form (Dipeptidyl peptidase 4 soluble form also named SDPP) derives from the membrane form (Dipeptidyl peptidase 4 membrane form also named MDPP) by proteolytic processing.; N- and O-Glycosylated.; Phosphorylated. Mannose 6-phosphate residues in the carbohydrate moiety are necessary for interaction with IGF2R in activated T-cells. Mannose 6-phosphorylation is induced during T-cell activation.

SUBCELLULAR LOCATION

Secreted, Cell membrane, Apical cell membrane, invadopodium membrane, lamellipodium membrane, Cell junction, Membrane raft.

FUNCTION

CD26 (dipeptidylpeptidase 4, adenosine deaminase complexing protein 2, ADABP, ADCP2, DPPIV, TP103) is a membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. CD26 has an essential role in immune regulation as a T cell activation molecule and a regulator of chemokine function. CD26 associates with CXCR4 and gp120 and may influence the pathophysiology of HIV infection. Adenosine deaminase (ADA) colocalizing with adenosine receptors on dendritic cells are able to interact with CD26 expressed on lymphocytes. This costimulatory signal in the immunological synapse leads to an increase in the production of the T helper 1 and proinflammatory cytokines IFN-gamma, TNF-alpha, and IL-6. CD26 plays a role in the pathogenesis and behavior of human cancers, including solid tumors and hematological malignancies. CD26-caveolin-1 interaction plays a role in the up-regulation of CD86 on TT-loaded monocytes and subsequent engagement with CD28 on T cells, leading to antigen-specific T cell activation.