NOX2/gp91phox Rabbit Polyclonal Antibody (ER1511-34)

UNIPROT #

P04839

PROTEIN NAME

NOX2/gp91phox

SYNONYMS

AMCBX2 antibody;CGD antibody;CGD91-phox antibody;CY24B_HUMAN antibody;CYBB antibody;Cytochrome b 245, beta polypeptide antibody;Cytochrome b(558) beta chain antibody;Cytochrome b(558) subunit beta antibody;Cytochrome b-245 heavy chain antibody;Cytochrome b558 subunit beta antibody;GP91 PHOX antibody;gp91-1 antibody;gp91-phox antibody;GP91PHOX antibody;Heme-binding membrane glycoprotein gp91phox antibody;NADPH oxidase 2 antibody;Neutrophil cytochrome b 91 kDa polypeptide antibody;NOX2 antibody;p22 phagocyte B-cytochrome antibody;P91 PHOX antibody;p91-PHOX antibody;Superoxide-generating NADPH oxidase heavy chain subunit antibody

TISSUE SPECIFICITY

Detected in neutrophils (at protein level).

POST-TRANSLATIONAL MODIFICATION

Glycosylated.; Phosphorylated on Ser and Thr residues.; Undergoes 'Lys-48'-linked polyubiquitination, likely by RNF145, triggering endoplasmic reticulum-associated degradation.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Mox1 and the glycoprotein gp91-phox are largely related proteins that are essential components of the NADPH oxidase. The superoxide-generating NADPH oxidase is present in phagocytes, neuroepithelial bodies, vascular smooth muscle cells and endothelial cells. It includes a membrane-bound flavocytochrome containing two subunits, gp91-phox and p22-phox, and the cytosolic proteins p47-phox and p67-phox. The p22- and gp91-phox subunits also function as surface O2 sensors that initiate cellular signaling in response to hypoxic conditions. Mox1 and gp91 contain identical C-terminal sequence identity, yet they have distinct expression patterns. gp91-phox is expressed in eosinophils, neutro-phils, monocytes and B-lymphocytes, whereas Mox1 is predominantly detected in the colon, and low expression is also detected in the uterus and prostate. Mox1 is also upregulated in vascular smooth-muscle cells in response to PDGF stimulation, which collectively indicates that Mox1 may function analogously to gp91-phox, yet regulate the NADPH superoxide production in non-phagocytic cells.