CD276 Rabbit Polyclonal Antibody (ER1803-36)

UNIPROT #

Q5ZPR3

PROTEIN NAME

CD276

SYNONYMS

4Ig B7 H3 antibody;4Ig-B7-H3 antibody;AU016588 antibody;B7 H3 antibody;B7 homolog 3 antibody;B7-H3 antibody;B7H3 antibody;B7RP-2 antibody;CD_antigen=CD276 antibody;CD276 antibody;CD276 antigen antibody;CD276 molecule antibody;CD276_HUMAN antibody;Costimulatory molecule antibody;Flags: Precursor antibody;PSEC0249 antibody;UNQ309/PRO352 antibody

SEQUENCE SIMILARITIES

Belongs to the immunoglobulin superfamily. BTN/MOG family.

TISSUE SPECIFICITY

Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.