Cyclophilin A Recombinant Rabbit Monoclonal Antibody [JM107-03] (ET1703-33)

UNIPROT #

P62937

PROTEIN NAME

Cyclophilin A

SYNONYMS

Cyclophilin A antibody;Cyclophilin antibody;CyclophilinA antibody;Cyclosporin A binding protein antibody;Cyclosporin A-binding protein antibody;CYPA antibody;CYPH antibody;Epididymis secretory sperm binding protein Li 69p antibody;HEL S 69p antibody;MGC117158 antibody;MGC12404 antibody;MGC23397 antibody;Peptidyl prolyl cis trans isomerase A antibody;Peptidyl-prolyl cis-trans isomerase A antibody;Peptidylprolyl isomerase A (cyclophilin A) antibody;Peptidylprolyl isomerase A antibody;PPIA antibody;PPIA protein antibody;PPIA_HUMAN antibody;PPIase A antibody;Rotamase A antibody;RotamaseA antibody;T cell cyclophilin antibody

SEQUENCE SIMILARITIES

Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.

POST-TRANSLATIONAL MODIFICATION

Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization and stabilizes cis rather than trans forms of the HIV-1 capsid. PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Secreted.

FUNCTION

The immunosuppressant cyclosporin A (CsA) forms a trimolecular complex with cyclophilin and calcineurins to inhibit calcineurin phosphatase activity. Cyclophilins are conserved, ubiquitous and abundant cytosolic peptidyl-prolyl cis-trans isomerases that accelerate the isomerization of XaaPro peptide bonds and the refolding of proteins. Human cyclophilin A (CyPA), an intracellular protein of 165 amino acids, is the target of the CsA and is encoded by a single unique gene conserved from yeast to humans. CyPA is known for its involvement in T cell differentiation and proliferation and is highly expressed in brain. CyPA is incorporated into the virion of the type 1 human immunodeficiency virus (HIV-1) via a direct interaction with the capsid domain of the viral Gag polyprotein and is crucial for efficient viral replication. Cyclophilin B (CyPB) is a member of the cyclophilin family with specific N- and C-terminal extensions. Unlike CyPA, CyPB has a signal sequence leading to its translocation in the endoplasmic reticulum. CyPB is secreted in biological fluids such as blood or milk and binds to a specific receptor present on the human lymphoblastic cell line Jurkat and on human peripheral blood lymphocytes (9,10).