CCR3 Rabbit Polyclonal Antibody (HA500279)

UNIPROT #

P51677

PROTEIN NAME

CCR3

SYNONYMS

B chemokine receptor antibody;b-chemokine receptor antibody;C C chemokine receptor type 3 antibody;C C CKR 3 antibody;C-C chemokine receptor type 3 antibody;C-C CKR-3 antibody;CC chemokine receptor 3 antibody;CC chemokine receptor type 3 antibody;CC CKR 3 antibody;CC R3 antibody;CC-CKR-3 antibody;CCCKR3 antibody;CCR 3 antibody;CCR-3 antibody;CCR3 antibody;CCR3_HUMAN antibody;CD 193 antibody;CD193 antibody;CD193 antigen antibody;Chemokine (C C motif) receptor 3 antibody;chemokine (C-C motif) receptor 3 antibody;Chemokine (CC) receptor 1 like 2 antibody;Chemokine CC motif receptor 3 antibody;Chemokine receptor 3 antibody;CK R3 antibody;CKR 3 antibody;CKR3 antibody;CMKB R3 antibody;CMKBR 3 antibody;CMKBR1L2 antibody;CMKBR3 antibody;Eosinophil CC chemokine receptor 3 antibody;Eosinophil eotaxin receptor antibody;Eotaxin receptor antibody;Macrophage inflammatory protein 1 alpha receptor like 2 antibody;MGC102841 antibody;MIP1 Alpha RL2 antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

C-C chemokine receptor type 3 is a protein that in humans is encoded by the CCR3 gene. CCR3 has also recently been designated CD193 (cluster of differentiation 193). The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway, and possibly at sites of parasitic infection. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants encoding the same protein have been described.