BPI Recombinant Rabbit Monoclonal Antibody [SN06-63] (ET1611-6)

UNIPROT #

P17213

PROTEIN NAME

BPI

SYNONYMS

Bactericidal permeability-increasing protein antibody;bactericidal/permeability-increasing protein antibody;BPI antibody;BPI fold containing family D, member 1 antibody;BPIFD1 antibody;CAP 57 antibody;rBPI antibody;recombinant BPI holoprotein, rBPI antibody

SEQUENCE SIMILARITIES

Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

TISSUE SPECIFICITY

Restricted to cells of the myeloid series.

SUBCELLULAR LOCATION

Membrane, Secreted.

FUNCTION

The bactericidal permeability increasing protein (BPI) is an antibacterial and endotoxin-neutralizing molecule that is abundant in the granules of polymorphonuclear leukocytes (neutrophil granules). The 31.5-kb-long human BPI gene maps to chromosome 20q11.23-q12, contains 15 exons, and encodes a 456 amino acid protein. Epithelial cells which line mucosal surfaces are the first line of defense against bacterial invasion and infection. BPI localizes to the cell surface of epithelial cells and blocks endotoxin-mediated signaling, thereby protecting mucosal surfaces against gram-negative bacteria and their endotoxin. BPI, lipopolysaccharide binding protein (LBP), phospholipid transfer protein (PLTP), and cholesteryl ester transfer protein (CETP) constitutes a family of functionally related proteins.