BST2 Recombinant Rabbit Monoclonal Antibody [JU11-93] (ET1706-46)

UNIPROT #

Q10589

PROTEIN NAME

BST2

SYNONYMS

Bone marrow stromal antigen 2 antibody;Bone marrow stromal cell antigen 2 antibody;Bone marrow stromal cell antigen antibody;BST 2 antibody;BST-2 antibody;BST2 antibody;BST2_HUMAN antibody;CD 317 antibody;CD317 antibody;CD317 antigen antibody;HM1.24 antigen antibody;NPC A 7 antibody;Tetherin antibody

SEQUENCE SIMILARITIES

Belongs to the tetherin family.

TISSUE SPECIFICITY

Predominantly expressed in liver, lung, heart and placenta. Lower levels in pancreas, kidney, skeletal muscle and brain. Overexpressed in multiple myeloma cells. Highly expressed during B-cell development, from pro-B precursors to plasma cells. Highly expressed on T-cells, monocytes, NK cells and dendritic cells (at protein level).

POST-TRANSLATIONAL MODIFICATION

Monoubiquitinated by KSHV E3 ubiquitin-protein ligase K5, leading to its targeting to late endosomes and degradation.; The GPI anchor is essential for its antiviral activity.

SUBCELLULAR LOCATION

Golgi apparatus. Cell membrane.

FUNCTION

Tetherin, also known as bone marrow stromal antigen 2, is a lipid raft associated protein that in humans is encoded by the BST2 gene. In addition, tetherin has been designated as CD317 (cluster of differentiation 317). This protein is constitutively expressed in mature B cells, plasma cells and plasmacytoid dendritic cells, and in many other cells, it is only expressed as a response to stimuli from IFN pathway. Tetherin is part of IFN-dependent antiviral response pathway. When the presence of virus and viral components is detected by recognition molecules such as (RIG-I), a cascades of interactions happen between signaling molecules, eventually the signal reaches the nucleus to upregulate the expression of interferon-stimulated genes (ISGs), this in turn activates IFN-α pathway to send the signal to neighboring cells, which causes upregulation in the expression of other ISGs and many viral restriction factors, such as tetherin.