CBARA1 Rabbit Polyclonal Antibody (ER1803-99)

UNIPROT #

Q9BPX6

PROTEIN NAME

CBARA1

SYNONYMS

Allergen Hom s 4 antibody;ara CALC antibody;atopy related autoantigen antibody;atopy related autoantigen CALC antibody;Atopy-related autoantigen CALC antibody;CALC antibody;calcium binding atopy related autoantigen 1 antibody;Calcium uptake protein 1 antibody;calcium uptake protein 1, mitochondrial antibody;Calcium-binding atopy-related autoantigen 1 antibody;CBARA1 antibody;EFHA3 antibody;FLJ12684 antibody;MICU1 antibody;MICU1_HUMAN antibody;mitochondrial antibody;mitochondrial calcium uptake 1 antibody;MPXPS antibody

SEQUENCE SIMILARITIES

Belongs to the MICU1 family. MICU1 subfamily.

TISSUE SPECIFICITY

Expressed in epithelial cell lines. Strongly expressed in epidermal keratinocytes and dermal endothelial cells.

SUBCELLULAR LOCATION

Mitochondrion.

FUNCTION

Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening. Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG. Alternatively spliced transcript variants encoding different isoforms have been described.