PRDM1 Rabbit Polyclonal Antibody (HA500255)

UNIPROT #

O75626

PROTEIN NAME

PRDM1

SYNONYMS

B Lymphocyte Induced Maturation Protein 1 antibody;Beta interferon gene positive regulatory domain I binding factor antibody;Beta-interferon gene positive regulatory domain I-binding factor antibody;BLIMP-1 antibody;BLIMP1 antibody;Positive Regulatory Domain I Binding Factor 1 antibody;Positive regulatory domain I-binding factor 1 antibody;PR Domain Containing 1 antibody;PR domain containing 1 with ZNF domain antibody;PR domain containing 1 with ZNF domain isoform 2 antibody;PR domain containing protein 1 antibody;PR domain zinc finger protein 1 antibody;PR domain-containing protein 1 antibody;PRDI BF1 antibody;PRDI binding factor 1 antibody;PRDI-BF1 antibody;PRDI-binding factor 1 antibody;PRDM 1 antibody;Prdm1 antibody;PRDM1_HUMAN antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity). Binds specifically to the PRDI element in the promoter of the beta-interferon gene . Drives the maturation of B-lymphocytes into Ig secreting cells . Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (By similarity).