STING Recombinant Rabbit Monoclonal Antibody [PSH07-44] (HA722832)

UNIPROT #

Q86WV6

PROTEIN NAME

STING

SYNONYMS

endoplasmic reticulum IFN stimulator antibody;Endoplasmic reticulum interferon stimulator antibody;ERIS antibody;FLJ38577 antibody;hMITA antibody;hSTING antibody;Mediator of IRF3 activation antibody;MITA antibody;Mitochondrial mediator of IRF3 activation antibody;MPYS antibody;N terminal methionine proline tyrosine serine plasma membrane tetraspanner antibody;NET23 antibody;Stimulator of interferon genes antibody;Stimulator of interferon genes protein antibody;STING antibody;TM173_HUMAN antibody;Tmem173 antibody;Transmembrane protein 173 antibody

SUBCELLULAR LOCATION

Endoplasmic reticulum membrane, Cytoplasm, perinuclear region, Endoplasmic reticulum-Golgi intermediate compartment membrane, Golgi apparatus membrane, Cytoplasmic vesicle, autophagosome membrane, Mitochondrion outer membrane, Cell membrane.

FUNCTION

Stimulator of interferon genes (STING), also known as transmembrane protein 173 (TMEM173) and MPYS/MITA/ERIS is a protein that in humans is encoded by the STING1 gene. STING plays an important role in innate immunity. STING induces type I interferon production when cells are infected with intracellular pathogens, such as viruses, mycobacteria and intracellular parasites.Type I interferon, mediated by STING, protects infected cells and nearby cells from local infection by binding to the same cell that secretes it (autocrine signaling) and nearby cells (paracrine signaling.) It thus plays an important role, for instance, in controlling norovirus infection. STING works as both a direct cytosolic DNA sensor (CDS) and an adaptor protein in Type I interferon signaling through different molecular mechanisms. It has been shown to activate downstream transcription factors STAT6 and IRF3 through TBK1, which are responsible for antiviral response and innate immune response against intracellular pathogen.