TCTP Recombinant Rabbit Monoclonal Antibody [JU13-32] (ET1706-48)

UNIPROT #

P13693

PROTEIN NAME

TCTP

SYNONYMS

FLJ27337 antibody;Fortilin antibody;Histamine releasing factor antibody;Histamine-releasing factor antibody;HRF antibody;Immunoglobulin E-dependent antibody;p02 antibody;p23 antibody;TCTP antibody;TCTP_HUMAN antibody;tpt1 antibody;Translationally controlled tumor protein antibody;Translationally-controlled tumor protein antibody;Tumor protein translationally controlled 1 antibody;tumor protein, translationally-controlled 1 antibody

SEQUENCE SIMILARITIES

Belongs to the TCTP family.

TISSUE SPECIFICITY

Found in several healthy and tumoral cells including erythrocytes, hepatocytes, macrophages, platelets, keratinocytes, erythroleukemia cells, gliomas, melanomas, hepatoblastomas, and lymphomas. It cannot be detected in kidney and renal cell carcinoma (RCC). Expressed in placenta and prostate.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Histamine-releasing factor (HRF) is a cytokine-like molecule that causes the release of histamine, IL-4 and IL-13 from basophils as well as the secretion of IL-8 and a calcium response in eosinophils. HRF belongs to the translationally controlled tumor protein (TCTP) family. It is expressed in several healthy and tumoral cells, including erythrocytes, hepatocytes, macrophages, platelets, keratinocytes, erythroleukemia cells, gliomas, melanomas, hepatoblastomas and lymphomas, and it is localized in the cytoplasm. HRF plays a pivotal role in allergic diseases, and due to its wide distribution in brain, is thought to be involved in neurodegenerative disorders, such as Alzheimer's disease and Down syndrome.