TLR5 Recombinant Rabbit Monoclonal Antibody [JM10-88] (ET1703-30)

UNIPROT #

O60602

PROTEIN NAME

TLR5

SYNONYMS

FLJ10052 antibody;MGC126430 antibody;MGC126431 antibody;SLEB1 antibody;TIL 3 antibody;TIL3 antibody;TLR 5 antibody;Tlr5 antibody;TLR5_HUMAN antibody;Toll like receptor 5 antibody;Toll like receptor 5 precursor antibody;Toll-like receptor 5 antibody;Toll/interleukin 1 receptor like protein 3 antibody;Toll/interleukin-1 receptor-like protein 3 antibody

SEQUENCE SIMILARITIES

Belongs to the Toll-like receptor family.

TISSUE SPECIFICITY

Highly expressed on the basolateral surface of intestinal epithelia. Expressed also in other cells such as lung epithelial cells.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated at Ser-805 by PKD/PRKD1; phosphorylation induces the production of inflammatory cytokines.; Phosphorylated at Tyr-798 upon flagellin binding; required for signaling.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

Toll-like receptor 5, also known as TLR5, is a protein which in humans is encoded by the TLR5 gene. It is a member of the toll-like receptor (TLR) family. The TLR family plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR5 is expressed on both immune and non-immune cells. TLR5 recognizes bacterial flagellin, a principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-κB and stimulates tumor necrosis factor-alpha production. TLR5 recognizes flagellin, which is the protein monomer that makes up the filament of bacterial flagella, found on nearly all motile bacteria. There are highly conserved regions in the flagellin protein among all bacteria, facilitating the recognition of flagellin by a germ-line encoded receptor such as TLR5. However, some Proteobacteria flagella have acquired mutations preventing their recognition by TLR5.