IL-5RA Rabbit Polyclonal Antibody (HA500303)

UNIPROT #

Q01344

PROTEIN NAME

IL-5RA

SYNONYMS

CD125 antibody;CD125 antigen antibody;CDw125 antibody;HSIL5R3 antibody;IL-5 receptor subunit alpha antibody;IL-5R subunit alpha antibody;IL-5R-alpha antibody;IL-5RA antibody;IL5R antibody;IL5RA antibody;IL5RA_HUMAN antibody;Interleukin 5 Receptor alpha antibody;Interleukin 5 Receptor alpha chain antibody;Interleukin 5 receptor alpha subunit antibody;Interleukin 5 receptor subunit alpha antibody;Interleukin 5 receptor type 3 antibody;Interleukin-5 receptor subunit alpha antibody;MGC26560 antibody

SUBCELLULAR LOCATION

Membrane.

FUNCTION

The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported.