IKK alpha Recombinant Rabbit Monoclonal Antibody [SN06-99] (ET1611-15)

UNIPROT #

O15111

PROTEIN NAME

IKK alpha

SYNONYMS

chuk antibody;CHUK1 antibody;Conserved Helix Loop Helix Ubiquitous Kinase antibody;Conserved helix loop ubiquitous kinase antibody;Conserved helix-loop-helix ubiquitous kinase antibody;I Kappa B Kinase 1 antibody;I Kappa B Kinase Alpha antibody;I-kappa-B kinase 1 antibody;I-kappa-B kinase alpha antibody;IkappaB kinase antibody;IkB kinase alpha subunit antibody;IkBKA antibody;IKK 1 antibody;IKK A antibody;IKK a kinase antibody;IKK-A antibody;IKK-alpha antibody;IKK1 antibody;IKKA antibody;IKKA_HUMAN antibody;Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells antibody;Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit antibody;Inhibitor of nuclear factor kappa-B kinase subunit alpha antibody;NFKBIKA antibody;Nuclear Factor Kappa B Inhibitor Kinase Alpha antibody;Nuclear factor NF kappa B inhibitor kinase alpha antibody;Nuclear factor NF-kappa-B inhibitor kinase alpha antibody;Nuclear factor NFkappaB inhibitor kinase alpha antibody;Nuclear Factor Of Kappa Light Chain Gene Enhancer In B Cells Inhibitor antibody;TCF-16 antibody;TCF16 antibody;Transcription factor 16 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.

TISSUE SPECIFICITY

Widely expressed.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by MAP3K14/NIK, AKT and to a lesser extent by MEKK1, and dephosphorylated by PP2A. Autophosphorylated.; (Microbial infection) Acetylation of Thr-179 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the I-kappa-B signaling pathway.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK-α) also known as IKK1 or conserved helix-loop-helix ubiquitous kinase (CHUK) is a protein kinase that in humans is encoded by the CHUK gene. IKK-α is part of the IκB kinase complex that plays an important role in regulating the NF-κB transcription factor. However, IKK-α has many additional cellular targets, and is thought to function independently of the NF-κB pathway to regulate epidermal differentiation. IKK-α is a member of the serine/threonine protein kinase family and forms a complex in the cell with IKK-β and NEMO. IKK-α has been shown to function in epidermal differentiation independently of the NF-κB pathway. The zebrafish homolog of IKK-α has also been shown to play a role in the differentiation of the embryonic epithelium. IκB kinase α (IKKα) is a regulator of keratinocyte terminal differentiation and proliferation and plays a role in skin cancer.