IKK alpha + IKK beta Recombinant Rabbit Monoclonal Antibody [SN63-02] (ET1611-23)

UNIPROT #

O14920

PROTEIN NAME

IKK alpha + IKK beta

SYNONYMS

CHUK antibody;Conserved helix loop helix ubiquitous kinase antibody;I kappa B kinase 1 antibody;I kappa B kinase 2 antibody;I Kappa B kinase alpha antibody;I Kappa B kinase beta antibody;IkB kinase alpha subunit antibody;IkBKA antibody;IkBKB antibody;IKK a kinase antibody;IKK alpha antibody;IKK beta antibody;IKK1 antibody;IKK2 antibody;IKKA antibody;IKKB antibody;IMD15 antibody;Inhibitor of kappa light polypeptide gene enhancer in B cells kinase beta antibody;Inhibitor of nuclear factor kappa-B kinase subunit alpha antibody;Inhibitor of nuclear factor kappa-B kinase subunit beta antibody;NFKBIKA antibody;NFKBIKB antibody;Nuclear factor NF kappa B inhibitor kinase beta antibody;Nuclear factor NFkappaB inhibitor kinase alpha antibody;TCF 16 antibody;TCF16 antibody;Transcription factor 16 antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Membrane raft.

FUNCTION

IKK-α is part of the IκB kinase complex that plays an important role in regulating the NF-κB transcription factor. IKK-β is an enzyme that serves as a protein subunit of IκB kinase, which is a component of the cytokine-activated intracellular signaling pathway involved in triggering immune responses. IKK's activity causes activation of a transcription factor known as Nuclear Transcription factor kappa-B or NF-κB. Activated IKK-β phosphorylates a protein called the inhibitor of NF-κB, IκB (IκBα), which binds NF-κB to inhibit its function. IKK-α and IKK-β phosphorylate the IκB proteins, marking them for degradation via ubiquitination and allowing NF-κB transcription factors to go into the nucleus. Once activated, NF-κB transcription factors regulate genes that are implicated in many important cellular processes, including immune response, inflammation, cell death, and cell proliferation.