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MEK7 Recombinant Rabbit Monoclonal Antibody [SD20-87] (ET1612-35)

Price: Regular price $385.00

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Catalog# ET1612-35

Rabbit Monoclonal to MEK7

Tested for

  • WB

  • IF-Cell

  • IF-Tissue

  • IHC-P

  • IP

  • FC

Reacts with

  • Human

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
Knock-Out or Knock-Down validated

Safety datasheet

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

MEK7 Recombinant Rabbit Monoclonal Antibody [SD20-87] (ET1612-35)

Immunogen

Synthetic peptide within human mek7 aa 370-419 / 419.

Host

Rabbit

Positive Control

A431, SHG-44, Hela, SH-SY-5Y, rat brain tissue, rat bladder tissue, mouse bladder tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

SD20-87

RRID

AB_3070108

APPLICATION DILUTION

  • WB

  • 1:1,000-1:2,000

  • IF-Cell

  • 1:50-1:200

  • IF-Tissue

  • 1:50-1:200

  • IHC-P

  • 1:50-1:200

  • FC

  • 1:50-1:100

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 47 kDa

Isotype

IgG

TARGET

UNIPROT #

O14733

PROTEIN NAME

MEK7

SYNONYMS

c-Jun N-terminal kinase kinase 2 antibody;Dual specificity mitogen activated protein kinase kinase 7 antibody;Dual specificity mitogen-activated protein kinase kinase 7 antibody;JNK activating kinase 2 antibody;JNK kinase 2 antibody;JNK-activating kinase 2 antibody;JNKK 2 antibody;Jnkk-2 antibody;Jnkk2 antibody;MAP kinase kinase 7 antibody;MAP2K7 antibody;MAPK/ERK kinase 7 antibody;MAPKK 7 antibody;MAPKK-7 antibody;MAPKK7 antibody;MEK 7 antibody;Mitogen Activated Protein Kinase kinase 7 antibody;MKK 7 antibody;MKK-7 antibody;MKK7 antibody;MP2K7_HUMAN antibody;PRKMK 7 antibody;PRKMK-7 antibody;PRKMK7 antibody;SAPK kinase 4 antibody;SAPKK-4 antibody;SAPKK4 antibody;Sek 2 antibody;Sek-2 antibody;Sek2 antibody;SKK4 antibody;stress-activated protein kinase kinase 4 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.

TISSUE SPECIFICITY

Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle.

POST-TRANSLATIONAL MODIFICATION

Activated by phosphorylation on Ser-271 and Thr-275 by MAP kinase kinase kinases (MAP3Ks).

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

A family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. The prototype member of this family, designated MAP kinase kinase, or MEK-1, specifically phosphorylates the MAP kinase regulatory threonine and tyrosine residues present in the Thr-Glu-Tyr motif of ERK. A second MEK family member, MEK-2, resembles MEK-1 in its substrate specificity. MEK-3 (or MKK-3) functions to activate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activates both p38 and JNK MAP kinases. MEK-5 appears to specifically phosphorylate ERK5, whereas MEK-6 phosphorylates p38 and p38b. MEK-7 (or MKK-7) phosphorylates and activates the JNK signal transduction pathway.

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