MyD88 Recombinant Rabbit Monoclonal Antibody [SC65-04] (ET1610-81)

UNIPROT #

Q99836

PROTEIN NAME

MyD88

SYNONYMS

Mutant myeloid differentiation primary response 88 antibody;MYD 88 antibody;Myd88 antibody;MYD88_HUMAN antibody;MYD88D antibody;Myeloid differentiation marker 88 antibody;Myeloid differentiation primary response 88 antibody;Myeloid differentiation primary response gene (88) antibody;Myeloid differentiation primary response gene 88 antibody;Myeloid differentiation primary response gene antibody;Myeloid differentiation primary response protein MyD88 antibody;OTTHUMP00000161718 antibody;OTTHUMP00000208595 antibody;OTTHUMP00000209058 antibody;OTTHUMP00000209059 antibody;OTTHUMP00000209060 antibody

TISSUE SPECIFICITY

Ubiquitous.

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination. OTUD4 specifically hydrolyzes 'Lys-63'-linked polyubiquitinated MYD88.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Interleukin-1 (IL-1)-induced activation of the NFκB pathway is mediated through the IL-1 receptor and the subsequent phosphorylation of IL-1 receptor-associated kinase (IRAK). The myeloid differentiation protein MyD88 was originally characterized as a protein upregulated in myeloleukemic cells following IL-6-induced growth arrest and terminal differentiation. MyD88 is now known to function as an adaptor protein for the association of IRAK with the IL-1 receptor. MyD88 is functionally homologous to the adaptor protein tube in the Toll signaling pathway of Drosophilia, and both proteins are members of the Toll/IL-1R superfamily. MyD88 contains a characteristic N-terminal death domain that is essential for NFκB activation and an adjacent Toll/IL-1R homology domain (TIR domain). Collectively, these domains enable the protein-protein interactions of MyD88 with IRAK and the IL-1 receptor complex.