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p38 Recombinant Rabbit Monoclonal Antibody [JF55-07] (ET1702-65)

Price: Regular price $385.00

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Catalog# ET1702-65

Rabbit Monoclonal to p38

Tested for

  • WB

  • IF-Cell

  • IF-Tissue

  • IHC-P

  • FC

Reacts with

  • Human

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
Knock-Out or Knock-Down validated
This product has been cited in peer reviewed publications, see list HERE

Safety datasheet

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

p38 Recombinant Rabbit Monoclonal Antibody [JF55-07] (ET1702-65)

Immunogen

Synthetic peptide within c-terminal human mapk14.

Host

Rabbit

Positive Control

HeLa cell lysate, Jurkat cell lysate, HEK-293 cell lysate, NIH/3T3 cell lysate, Neuro-2a cell lysate, RAW264.7 cell lysate, PC-12 cell lysate, C6 cell lysate, THP-1 cell lysate, C2C12 cell lysate, Rat kidney tissue lysate, Mouse kidney tissue lysate, RAW264.7, PC-12, HeLa, mouse heart tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JF55-07

RRID

AB_3073466

APPLICATION DILUTION

  • WB

  • 1:2,000-1:5,000

  • IF-Cell

  • 1:100

  • IF-Tissue

  • 1:50-1:200

  • IHC-P

  • 1:50-1:200

  • FC

  • 1:1,000

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 41 kDa

Isotype

IgG

TARGET

UNIPROT #

Q16539

PROTEIN NAME

p38

SYNONYMS

CSAID-binding protein antibody;Csaids binding protein antibody;CSBP antibody;CSBP1 antibody;CSBP2 antibody;CSPB1 antibody;Cytokine suppressive anti-inflammatory drug-binding protein antibody;EXIP antibody;MAP kinase 14 antibody;MAP kinase MXI2 antibody;MAP kinase p38 alpha antibody;MAPK 14 antibody;MAPK14 antibody;MAX-interacting protein 2 antibody;Mitogen-activated protein kinase 14 antibody;Mitogen-activated protein kinase p38 alpha antibody;MK14_HUMAN antibody;Mxi2 antibody;p38 antibody;p38 MAP kinase antibody;p38 mitogen activated protein kinase antibody;p38ALPHA antibody;p38alpha Exip antibody;PRKM14 antibody;PRKM15 antibody;RK antibody;SAPK2A antibody;Stress-activated protein kinase 2a antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

TISSUE SPECIFICITY

Brain, heart, placenta, pancreas and skeletal muscle. Expressed to a lesser extent in lung, liver and kidney.

POST-TRANSLATIONAL MODIFICATION

Dually phosphorylated on Thr-180 and Tyr-182 by the MAP2Ks MAP2K3/MKK3, MAP2K4/MKK4 and MAP2K6/MKK6 in response to inflammatory citokines, environmental stress or growth factors, which activates the enzyme. Dual phosphorylation can also be mediated by TAB1-mediated autophosphorylation. TCR engagement in T-cells also leads to Tyr-323 phosphorylation by ZAP70. Dephosphorylated and inactivated by DUPS1, DUSP10 and DUSP16. PPM1D also mediates dephosphorylation and inactivation of MAPK14.; Acetylated at Lys-53 and Lys-152 by KAT2B and EP300. Acetylation at Lys-53 increases the affinity for ATP and enhances kinase activity. Lys-53 and Lys-152 are deacetylated by HDAC3.; Ubiquitinated. Ubiquitination leads to degradation by the proteasome pathway.

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

MAP (mitogen-activated protein) kinases play a significant role in many biological processes, including cell adhesion and spreading, cell differentiation and apoptosis. p38α, p38β and p38γ, also known as MAPK14, MAPK11 and MAPK12, respectively, each contain one protein kinase domain and belong to the MAP kinase family. Expressed in different areas throughout the body with common expression patterns in heart, p38 proteins use magnesium as a cofactor to catalyze the ATP-dependent phosphorylation of target proteins. Via their catalytic activity, p38α, p38β and p38γ are involved in a variety of events throughout the cell, including signal transduction pathways, cytokine production and cell proliferation and differentiation. The p38 proteins are subject to phosphoryation on Thr and Tyr residues, an event which is thought to activate the phosphorylated protein.

CITATIONS

  • Pan, G., Zhong, M., Yao, J., Tan, J., Zheng, H., Jiang, Y., Tang, Y., Zhou, H., Qin, D., Yu, X., Liu, L., Li, Z., Lin, Z., Jiang, Y., Xu, B., & Zha, J.

    Orelabrutinib and venetoclax synergistically induce cell death in double hit lymphoma by interfering with the crosstalk between the PI3K/AKT and p38/MAPK signaling

  • Wang Jinyang,et al

    Edaravone Dexborneol ameliorates the cognitive deficits of APP/PS1 mice by inhibiting TLR4/MAPK signaling pathway via upregulating TREM2

  • Cheng Lin,et al

    Hemodynamic force dictates endothelial angiogenesis through MIEN1-ERK/MAPK-signaling axis

  • SETDB1-mediated CD147-K71 di-methylation promotes cell apoptosis in non-small cell lung cancer

  • PER3 plays anticancer roles in the oncogenesis and progression of breast cancer via regulating MEK/ERK signaling pathway

  • Fanwei Liu ,et al

    MicroRNA-122 protects against interferon-α-induced hepatic inflammatory response via the Janus kinase–signal transducer and activator of transcription pathway

  • Hyperglycemia modulates M1/M2 macrophage polarization via reactive oxygen species overproduction in ligature-induced periodontitis

  • Chen Lingfeng,et al

    Discovery of LC-MI-3: A Potent and Orally Bioavailable Degrader of Interleukin-1 Receptor-Associated Kinase 4 for the Treatment of Inflammatory Diseases

  • Chunyan Dong,et al

    GLP-1RAs attenuated obesity and reversed leptin resistance partly via activating the microbiome-derived inosine/A2A pathway

  • Li Xinhao,et al

    The Link between Osteoporosis and Frozen Shoulder: Exploring the Therapeutic Effect of TAK715 on Reversing Fibrosis and Protecting against Osteoporosis via the p38 MAPK Signaling Pathway

  • He Mengni,et al

    Exploring novel indazole derivatives as ASK1 inhibitors: design, synthesis, biological evaluation and docking studies

  • Yuejia Li,et al

    Zinc Attenuates Bisphenol A-Induced Reproductive Toxicity in Male Mice by Inhibiting Ferroptosis and Apoptosis Through Improving Zinc Homeostasis

  • Wang Jianfeng,et al

    Anshen Shumai Decoction inhibits post-infarction inflammation and myocardial remodeling through suppression of the p38 MAPK/c-FOS/EGR1 pathway

  • Lu Py,et al

    Effect and mechanism of recombinant human fibroblast growth factor 18 on osteoporosis in OVX mice

  • Yu Qiwen,et al

    Nepetoidin B Alleviates Liver Ischemia/Reperfusion Injury via Regulating MKP5 and JNK/P38 Pathway

  • Jun-Xing Zhu,et al

    Intervention effect of regulating GABA-A receptor activity on the formation of experimental abdominal aortic aneurysm in rats

  • Yongru Zhou,et al

    Bisphenol S exposure interrupted human embryonic stem cell derived cardiomyocytes differentiation through ER-NF-κB/ERK signaling pathway

  • CD147 Mediates 5-Fluorouracil Resistance in Colorectal Cancer by Reprogramming Glycolipid Metabolism

  • Jiang, S., Xu, C. M., Yao, S., Zhang, R., Li, X. Z., Zhang, R. Z., Xie, T. Y., Xing, Y. Q., Zhang, Q., Zhou, X. J., Liao, L., & Dong, J. J.

    Cdc42 upregulation under high glucose induces podocyte apoptosis and impairs b-cell insulin secretion

  • Sun Zhijian,et al

    H9N2 Avian Influenza Virus Downregulates FcRY Expression in Chicken Macrophage Cell Line HD11 by Activating the JNK MAPK Pathway

  • The RasGEF MoCdc25 regulates vegetative growth, conidiation and appressorium-mediated infection in the rice blast fungus Magnaporthe oryzae

  • Yizhen Wang

    Biogenic nanoselenium particles activate Nrf2-ARE pathway by phosphorylating p38,ERK1/2,and AKT on IPEC-J2 cells.

    • WB

    • The porcine jejunum epithelial (IPEC‐J2) cells

    • Citation

  • Xu, Q., Ding, H., Li, S., Dong, S., Li, L., Shi, B., Zhong, M., & Zhang, G.

    Sleeve Gastrectomy Ameliorates Diabetes-Induced Cardiac Hypertrophy Correlates With the MAPK Signaling Pathway

  • Downregulation of AC092894. 1 promotes oxaliplatin resistance in colorectal cancer via the USP3/AR/RASGRP3 axis

  • Geng Xiaoyu,et al

    Comparative Analysis of Tentacle Extract and Nematocyst Venom: Toxicity, Mechanism, and Potential Intervention in the Giant Jellyfish Nemopilema nomurai

  • Mettl3 Deficiency Sustains Long-Chain Fatty Acid Absorption through Suppressing Traf6-Dependent Inflammation Response

  • Yin, P., Li, D., Zhao, Q., Cai, M., Wu, Z., Shi, Y., & Su, L.

    Gsα deficiency facilitates cardiac remodeling via CREB/ Bmp10-mediated signaling

  • Song, D., Liu, Y., Yao, Y., Liu, F., Tao, W., Zhou, X., Li, R., Zhang, X., & Li, X.

    Melatonin improves bisphenol A-induced cell apoptosis, oxidative stress and autophagy impairment via inhibition of the p38 MAPK signaling pathway in FLK-BLV cells

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