Phospho-Creb (S133) Recombinant Rabbit Monoclonal Antibody [JB25-40] (ET7107-93)

UNIPROT #

P16220

PROTEIN NAME

Phospho-Creb (S133)

SYNONYMS

Active transcription factor CREB antibody;cAMP response element binding protein 1 antibody;cAMP response element binding protein antibody;cAMP responsive element binding protein 1 antibody;cAMP-responsive element-binding protein 1 antibody;CREB antibody;CREB-1 antibody;CREB1 antibody;CREB1_HUMAN antibody;Cyclic AMP-responsive element-binding protein 1 antibody;MGC9284 antibody;OTTHUMP00000163864 antibody;OTTHUMP00000163865 antibody;OTTHUMP00000206660 antibody;OTTHUMP00000206662 antibody;OTTHUMP00000206667 antibody;Transactivator protein antibody

SEQUENCE SIMILARITIES

Belongs to the bZIP family.

POST-TRANSLATIONAL MODIFICATION

Stimulated by phosphorylation. Phosphorylation of both Ser-133 and Ser-142 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-133 allows CREBBP binding. In liver, phosphorylation is induced by fasting or glucagon in a circadian fashion (By similarity). CREBL2 positively regulates phosphorylation at Ser-133 thereby stimulating CREB1 transcriptional activity (By similarity). Phosphorylated upon calcium influx by CaMK4 and CaMK2 on Ser-133. CaMK4 is much more potent than CaMK2 in activating CREB. Phosphorylated by CaMK2 on Ser-142. Phosphorylation of Ser-142 blocks CREB-mediated transcription even when Ser-133 is phosphorylated. Phosphorylated by CaMK1 (By similarity). Phosphorylation of Ser-271 by HIPK2 in response to genotoxic stress promotes CREB1 activity, facilitating the recruitment of the coactivator CBP. Phosphorylated at Ser-133 by RPS6KA3, RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli. Phosphorylated by TSSK4 on Ser-133.; Sumoylated with SUMO1. Sumoylation on Lys-304, but not on Lys-285, is required for nuclear localization of this protein. Sumoylation is enhanced under hypoxia, promoting nuclear localization and stabilization.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.