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CD80/B7-1 Mouse Monoclonal Antibody [8-E5] (M1007-10)

Price: Regular price $350.00

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Catalog# M1007-10

Mouse Monoclonal to CD80/B7-1

Tested for

  • WB

  • IF-Cell

  • IHC-P

  • FC

Reacts with

  • Human

  • Mouse

This product has been cited in peer reviewed publications, see list HERE

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Specifications

Product Type

Mouse monoclonal primary

Product Name

CD80/B7-1 Mouse Monoclonal Antibody [8-E5] (M1007-10)

Immunogen

Synthetic peptide within human cd80 aa 74-118 / 288.

Host

Mouse

Positive Control

Human brain tissue lysates, human brain tissue, SH-SY5Y, Hela.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

8-E5

RRID

AB_3073017

APPLICATION DILUTION

  • WB

  • 1:1,000

  • IF-Cell

  • 1:100-1:200

  • IHC-P

  • 1:50

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

2ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 33 kDa

Isotype

IgG2b

TARGET

UNIPROT #

P33681

PROTEIN NAME

CD80/B7-1

SYNONYMS

Activation B7-1 antigen antibody;B lymphocyte activation antigen B7 antibody;B7 antibody;B7-1 antibody;B7-1 antigen antibody;B7.1 antibody;BB1 antibody;CD28 antigen ligand 1 antibody;CD28LG antibody;CD28LG1 antibody;CD80 antibody;CD80 antigen (CD28 antigen ligand 1, B7-1 antigen) antibody;CD80 antigen antibody;CD80 molecule antibody;CD80_HUMAN antibody;Costimulatory factor CD80 antibody;costimulatory molecule variant IgV-CD80 antibody;CTLA-4 counter-receptor B7.1 antibody;LAB7 antibody;T-lymphocyte activation antigen CD80 antibody

TISSUE SPECIFICITY

Expressed on activated B-cells, macrophages and dendritic cells.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

CD80/B7-1 is a molecule found on activated B cells and monocytes which provides a costimulatory signal necessary for T cell activation and survival. After engagement of T-cell receptor with antigen in association with major histocompatibility complex class II, a second signal mediated through the binding of B7 to CD28 greatly upregulates the production of multiple lymphokines. B7-1 is a costimulatory molecule for the activation of both CD4+ and CD8+ T lymphocytes that prevents the induction of clonal anergy. Thus, the transfer of B7-1 genes into tumor cells can induce protective immunity and lead to tumor rejection of some tumors in model systems of in vivo tumor growth.

CITATIONS

  • Han, Z., Ma, J., Han, Y., Yuan, G., Jiao, R., & Meng, A.

    Irisin attenuates acute lung injury by suppressing the pyroptosis of alveolar macrophages

  • Jinghai Chen & Da-Zhi Wang

    Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction

  • Xia, H., Wang, Y., Dai, J., Zhang, X., Zhou, J., Zeng, Z., & Jia, Y.

    Selenoprotein K Is Essential for the Migration and Phagocytosis of Immature Dendritic Cells

  • Liang, L., Xu, W., Shen, A., Fu, X., Cen, H., Wang, S., Lin, Z., Zhang, L., Lin, F., Zhang, X., Zhou, N., Chang, J., Chen, Z. S., Li, C., & Yu, X.

    Inhibition of YAP1 activity ameliorates acute lung injury through promotion of M2 macrophage polarization

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