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CCL2 Rabbit Polyclonal Antibody (HA500267)

Price: Regular price $315.00

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Catalog# HA500267

Rabbit Polyclonal to CCL2

Tested for

  • WB

  • FC

Reacts with

  • Mouse

  • Human

This product has been cited in peer reviewed publications, see list HERE

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Specifications

Product Type

Rabbit polyclonal primary

Product Name

CCL2 Rabbit Polyclonal Antibody (HA500267)

Immunogen

Synthetic peptide within human ccl2 aa 30-70 / 99.

Host

Rabbit

Positive Control

Mouse testis tissue lysates.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3071363

APPLICATION DILUTION

  • WB

  • 1:500-1:1,000

  • FC

  • 1:500-1:1,000

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

Predicted band size: 11 kDa

Isotype

IgG

TARGET

UNIPROT #

P13500

PROTEIN NAME

CCL2

SYNONYMS

C-C motif chemokine 2 antibody;CCL2 antibody;CCL2_HUMAN antibody;Chemokine (C C motif) ligand 2 antibody;GDCF 2 antibody;GDCF-2 antibody;GDCF2 antibody;HC11 antibody;HSMCR30 antibody;JE antibody;MCAF antibody;MCP 1 antibody;MCP-1 antibody;MCP1 antibody;MGC9434 antibody;Monocyte chemoattractant protein 1 antibody;Monocyte chemotactic and activating factor antibody;Monocyte chemotactic protein 1 antibody;Monocyte secretory protein JE antibody;SCYA2 antibody;Small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig je) antibody;Small inducible cytokine A2 antibody;Small inducible cytokine subfamily A (Cys Cys), member 2 antibody;Small-inducible cytokine A2 antibody;SMC CF antibody;SMC-CF antibody;SMCCF antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

CCL2 exhibits a chemotactic activity for monocytes and basophils. However, it does not attract neutrophils or eosinophils. After deletion of the N-terminal residue, CCL2 loses its attractivity for basophils and becomes a chemoattractant of eosinophils. Basophils and mast cells that are treated with CCL2 release their granules to the intercellular space. This effect can be also potentiated by a pre-treatment with IL-3 or even by other cytokines. CCL2 augments monocyte anti-tumor activity and it is essential for formation of granulomas. CCL2 protein become a CCR2 antagonist when it is cleaved by metalloproteinase MMP-12.

CITATIONS

  • Wu, Q., Xu, R., Zhang, K., Sun, R., Yang, M., Li, K., Liu, H., Xue, Y., Xu, H., & Guo, Y.

    Characterization of early myocardial inflammation in ischemia-reperfusion injury

  • Linxi Lv , Hui Jiang , Dianze Song ,et al

    Sirt3 improves monosodium urate crystal-induced inflammation by suppressing Acod1 expression

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