BRG1 Recombinant Rabbit Monoclonal Antibody [SN20-03] (ET1611-85)

UNIPROT #

P51532

PROTEIN NAME

BRG1

SYNONYMS

ATP dependent helicase SMARCA4 antibody;ATP-dependent helicase SMARCA4 antibody;BAF 190 antibody;BAF190 antibody;BAF190A antibody;Brahma protein like 1 antibody;BRG1 antibody;BRG1 associated factor 190A antibody;BRG1 protein antibody;BRG1-associated factor 190A antibody;BRM/SWI2 related gene 1 antibody;Global transcription activator homologous sequence antibody;global transcription activator snf2l4 antibody;Homeotic gene regulator antibody;hSNF2b antibody;Mitotic growth and transcription activator antibody;MRD16 antibody;Nuclear protein GRB1 antibody;Protein brahma homolog 1 antibody;Protein BRG-1 antibody;Protein BRG1 antibody;RTPS2 antibody;SMARC A4 antibody;SMARCA4 antibody;SMCA4_HUMAN antibody;SNF2 antibody;SNF2 beta antibody;SNF2 like 4 antibody;SNF2-beta antibody;SNF2B antibody;SNF2L4 antibody;SNF2LB antibody;Sucrose nonfermenting like 4 antibody;SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 4 antibody;SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 antibody;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 antibody;SWI2 antibody;Transcription activator BRG1 antibody

SEQUENCE SIMILARITIES

Belongs to the SNF2/RAD54 helicase family.

TISSUE SPECIFICITY

Colocalizes with ZEB1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level).

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

The SWI-SNF complex is involved in the activation of transcription via the remodeling of nucleosome structure in an ATP-dependent manner. Brm (also designated SNF2α) and Brg-1 (also designated SNF2β) are the ATPase subunits of the mammalian SWI-SNF complex. Brm, Brg-1, Ini1 (integrase interactor 1, also designated SNF5), BAF155 (also designated SRG3) and BAF170 are thought to comprise the functional core of the SWI-SNF complex. Addition of Ini1, BAF155 and BAF170 to Brg-1 appears to increase remodeling activity. Other complex subunits are thought to play regulatory roles. hSNF2L and hSNF2H both appear to be homologs of Drosophila ISWI, a Brm related ATPase that is present in chromatin remodeling complexes other than SWI/SNF, including the NURF (nucleosome remodeling factor).