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Discovery of a potent and selective allosteric inhibitor targeting the SHP2 tunnel site for RTK-driven cancer treatment

Yang J, Yang Y, Wei Y, Wei X

A small-molecule pan-HER inhibitor alone or in combination with cisplatin exerts efficacy against nasopharyngeal carcinoma

Jian Li; Caiqiao Zhang

Metformin Prevents Follicular Atresia in Aging Laying Chickens through Activation of PI3K/AKT and Calcium Signaling Pathways

Yuyin Chen

Immune response of peroxinectin of chinese mitten crab eriocheir sinensis to exterior stimulation

MicroRNA-375 Mediated Regulation on Pre-mRNA Processing Factor 3 in Zebrafish Embryos Exposed to Di-(2-ethylhexyl)phthalate at Low Concentrations

Jin-Yan Li

Identification of Cancer Stem-Like Side Population Cells in Purified Primary Cultured Human Laryngeal Squamous Cell Carcinoma Epithelia

Lixin Wei

Autophagy protects against palmitate-induced apoptosis in hepatocytes

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Adenosine A2A receptor antagonist KW6002 protects against A53T mutant alpha-synuclein-induced brain damage and neuronal apoptosis in Parkinson's disease mice by restoring autophagic flux

Zong, X., Xiao, X., Shen, B., Jiang, Q., Wang, H., Lu, Z., Wang, F., Jin, M., Min, J., Wang, F., & Wang, Y.

The N6-methyladenosine RNA-binding protein YTHDF1 modulates the translation of TRAF6 to mediate the intestinal immune response. Nucleic acids research, 49(10), 5537–5552.

Wang Hong,et al

Hydrogel-immobilized nanotherapeutics: Inhibition of protective autophagy to amplify STING signals for postsurgical tumor immunotherapy

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The role of apoptosis, immunogenic cell death, and macrophage polarization in carbon ion radiotherapy for keloids: Targeting the TGF-β1/SMADs signaling pathway

A genome-wide CRISPR screen identifies the CCT chaperonin as a critical regulator of vesicle trafficking

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Discovery of novel peptide-dehydroepiandrosterone hybrids inducing endoplasmic reticulum stress with effective in vitro and in vivo anti-melanoma activities

Xiao, L. X., Qi, L., Zhang, X. L., Zhou, Y. Q., Yue, H. L., Yu, E. D., & Li, Q. Y.

Liver injury in septic mice were suppressed by a camptothecin-bile acid conjugate via inhibiting NF-κB signaling pathway. Life sciences, 257, 118130.

Liu Shengde,et al

Genome-wide CRISPR Screening Identifies the Pivotal Role of ANKRD42 in Colorectal Cancer Metastasis Through EMT Regulation

Wu, Y., Hu, A., Shu, X., Huang, W., Zhang, R., Xu, Y., & Yang, C.

Lactobacillus plantarum postbiotics trigger AMPK-dependent autophagy to suppress Salmonella intracellular infection and NLRP3 inflammasome activation

Cai Binhao,et al

Discovery of a doublecortin-like kinase 1 inhibitor to prevent inflammatory responses in acute lung injury

Gao Bingbing,et al

Beneficial Effects of Oxymatrine from Sophora flavescens on Alleviating by Improving Inflammation and Ferroptosis

Wang, J., Bai, Y., Yin, S., Cui, J., Zhang, Y., Wang, X., Zhang, F., Li, H., Tang, Y., & Wang, J.

Circadian clock gene BMAL1 reduces urinary calcium oxalate stones formation by regulating NRF2/HO-1 pathway. Life sciences, 265, 118853.

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Discovery of LC-MI-3: A Potent and Orally Bioavailable Degrader of Interleukin-1 Receptor-Associated Kinase 4 for the Treatment of Inflammatory Diseases

MiR‐17 family‐mediated regulation of Pknox1 influences hepatic steatosis and insulin signaling

Hua Zhang; Fang Kuang

Inhibition of MyD88 Signaling Skews Microglia/Macrophage Polarization and Attenuates Neuronal Apoptosis in the Hippocampus After Status Epilepticus in Mice

Inhibition of complement C3 signaling ameliorates locomotor and visual dysfunction in autoimmune inflammatory diseases

Sun, F., Zhao, Z., Willoughby, M. M., Shen, S., Zhou, Y., Shao, Y., Kang, J., Chen, Y., Chen, M., Yuan, X., Hamza, I., Reddi, A. R., & Chen, C.

HRG-9 homologues regulate haem trafficking from haem-enriched compartments

Song, X., Liu, B., Zhao, G., Pu, X., Liu, B., Ding, M., & Xue, Y.

Streptococcus pneumoniae promotes migration and invasion of A549 cells in vitro by activating mTORC2/AKT through up-regulation of DDIT4 expression

Liu, Y., Wang, C., Cheng, P., Zhang, S., Zhou, W., Xu, Y., Xu, H., & Ji, G.

FHL1 Inhibits the Progression of Colorectal Cancer by Regulating the Wnt/β-Catenin Signaling Pathway. Journal of Cancer, 12(17), 5345–5354.

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Coronavirus M protein promotes mitophagy over virophagy by recruiting PDPK1 to phosphorylate SQSTM1 at T138

Liu, X., Cui, S., Dan, C., Li, W., Xie, H., Li, C., & Shi, L.

Phellinus baumii Polyphenol: A Potential Therapeutic Candidate against Lung Cancer Cells

Luan Yi,et al

Linear ubiquitination regulates the KSHV replication and transcription activator protein to control infection

Shuxin Li,et al

Overcoming multi-drug resistance in SCLC: a synergistic approach with venetoclax and hydroxychloroquine targeting the lncRNA LYPLAL1-DT/BCL2/BECN1 pathway

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LTBP2 silence suppresses glioblastoma proliferation and tumor growth of Xenograft tumor mice through modulating JAK2/STAT3 signaling pathway

Guo-Kang Fan

Cancer-Associated Fibroblasts in a Human HEp-2 Established Laryngeal Xenografted Tumor Are Not Derived from Cancer Cells through Epithelial-Mesenchymal Transition,Phenotypically Activated but Karyotypically Normal

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A novel trifluoromethyl quinoline derivative targeting SGK1 inducing autophagy and apoptosis via regulating mTOR/FOXO3a pathway in glioblastoma

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Nucleophosmin 1a translocated from nucleus to cytoplasm and facilitate GCRV replication

Tetrahydropalmatine Prevents High-Fat Diet-Induced Hyperlipidemia in Golden Hamsters (Mesocricetus Auratus)

Huibin Qiu;Peifeng Liu

Selective Killing of Cancer Cells by Nonplanar Aromatic Hydrocarbon-Induced DNA Damage

Increase of PRPP enhances chemosensitivity of PRPS1 mutant acute lymphoblastic leukemia cells to 5‐Fluorouracil

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SNRK modulates mTOR-autophagy pathway for liver lipid homeostasis in MAFLD

Weiping Wang,Junli Zhen

Chronic mild hypoxia promotes hippocampal neurogenesis involving Notch1 signaling in epileptic rats.

Liao Zhi

Production and Function of Different Regions from Mytichitin-1 of Mytilus coruscus

Targeting DNA polymerase β elicits synthetic lethality with mismatch repair deficiency in acute lymphoblastic leukemia

Xiaoqiang Guo ,Xianglin Duan

Histone H3K9 demethylase JMJD1A is a co-activator of erythropoietin expression under hypoxia.

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Lycium barbarum glycopeptide ameliorates motor and visual deficits in autoimmune inflammatory diseases

PD184352 exerts anti-inflammatory and antioxidant effects by promoting activation of the Nrf2/HO-1 axis

Mo, F., Zhou, X., Yang, M., Chen, L., Tang, Z., Wang, C., & Cui, Y.

Trehalose Attenuates Oxidative Stress and Endoplasmic Reticulum Stress-Mediated Apoptosis in IPEC-J2 Cells Subjected to Heat Stress

Zhou, W., Shi, W., Du, X., Han, Y., Tang, Y., Ri, S., Ju, K., Kim, T., Huang, L., Zhang, W., Yu, Y., Tian, D., Yu, Y., Chen, L., Wu, Z., & Liu, G.

Assessment of Nonalcoholic Fatty Liver Disease Symptoms and Gut-Liver Axis Status in Zebrafish after Exposure to Polystyrene Microplastics and Oxytetracycline, Alone and in Combination

Pleiotrophin ameliorates age-induced adult hippocampal neurogenesis decline and cognitive dysfunction

Chengfei Xu,et al

Histone modifications and Sp1 promote GPR160 expression in bone cancer pain within rodent models

Yongjing Guo,et al

Maresin1 Inhibits Ferroptosis via the Nrf2/SLC7A11/GPX4 Pathway to Protect Against Sepsis-Induced Acute Liver Injury

Novel Dimeric Architecture of an IFN-γ–Related Cytokine Provides Insights into Subfunctionalization of Type II IFNs in Teleost Fish

Cheng, Y., Mo, F., Li, Q., Han, X., Shi, H., Chen, S., Wei, Y., & Wei, X.

Targeting CXCR2 inhibits the progression of lung cancer and promotes therapeutic effect of cisplatin. Molecular cancer, 20(1), 62.

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Claudin-18.2 mediated interaction of gastric Cancer cells and Cancer-associated fibroblasts drives tumor progression

Xiang, H., Shao, M., Lu, Y., Wang, J., Wu, T., & Ji, G.

Kaempferol Alleviates Steatosis and Inflammation During Early Non-Alcoholic Steatohepatitis Associated With Liver X Receptor α-Lysophosphatidylcholine Acyltransferase 3 Signaling Pathway. Frontiers in pharmacology, 12, 690736.

Wang F

Zebrafish slc30a10 deficiency revealed a novel compensatory mechanism of Atp2c1 in maintaining manganese homeostasis

Integrated Analysis of mRNA-seq and miRNA-seq to Identify c-MYC, YAP1 and miR-3960 as Major Players in the Anticancer Effects of Caffeic Acid Phenethyl Ester in Human Small Cell Lung Cancer Cell Line

Qingchang Suppository Ameliorates Colonic Vascular Permeability in Dextran-Sulfate-Sodium-Induced Colitis

Xinying Li,et al

Ghrelin regulates the endoplasmic reticulum stress signalling pathway in gestational diabetes mellitus

Jinrong Peng

Liver-Enriched Gene 1,a Glycosylated Secretory Protein,Binds to FGFR and Mediates an Anti-stress Pathway to Protect Liver Development in Zebrafish

Curcumol inhibits malignant biological behaviors and TMZ-resistance of glioma cells via reducing long noncoding RNA FoxD2-As1 promoted EZH2 activation

Wei-Qiang Tan;Jun Chen

p53 isoform Δ113p53 promotes zebrafish heart regeneration by maintaining redox homeostasis

Huang, J., Zhang, Q., Shen, J., Chen, X., & Ma, S.

Multi-omics analysis identifies potential mechanisms of AURKB in mediating poor outcome of lung adenocarcinoma.

Li Hui,et al

Folylpolyglutamate synthetase inactivation in relapsed ALL induces a druggable folate metabolic vulnerability

Xiang Zuo,et al

Fluoxetine Ameliorates Cognitive Deficits in High-Fat Diet Mice by Regulating BDNF Expression

Lixin Weib

Autophagy inhibits chemotherapy-induced apoptosis through downregulating Bad and Bim in hepatocellular carcinoma cells

Protective effects of epigallocatechin‐3‐o‐gallate combined with organic selenium against transforming growth factor‐beta 1‐induced fibrosis in LX‐2 cells

Zhang Zizhen,et al

Influential upregulation of KCNE4: Propelling cancer associated fibroblasts-driven colorectal cancer progression

Wang, C., Wei, S., Liu, B., Wang, F., Lu, Z., Jin, M., & Wang, Y.

Maternal consumption of a fermented diet protects offspring against intestinal inflammation by regulating the gut microbiota

Zhao Jinquan,et al

The anti-non-small cell lung cancer effect of Diosbulbin B: targeting YY1 induced cell cycle arrest and apoptosis

Zhu, Y., Wang, Y., Tao, B., Han, J., Chen, H., Zhu, Q., Huang, L., He, Y., Hong, J., Li, Y., Chen, J., Huang, J., Lo, L. J., & Peng, J.

Nucleolar GTPase Bms1 displaces Ttf1 from RFB-sites to balance progression of rDNA transcription and replication

Elucidation of the anti-colon cancer mechanism of Phellinus baumii polyphenol by an integrative approach of network pharmacology and experimental verification