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HDAC1 Recombinant Rabbit Monoclonal Antibody [SY12-04] (ET1605-35)

Price: Regular price $385.00

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Catalog# ET1605-35

Rabbit Monoclonal to HDAC1

Tested for

  • WB

  • IHC-P

  • IF-Cell

  • IP

  • IF-Tissue

Reacts with

  • Human

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
Knock-Out or Knock-Down validated
This product has been cited in peer reviewed publications, see list HERE

Safety datasheet

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

HDAC1 Recombinant Rabbit Monoclonal Antibody [SY12-04] (ET1605-35)

Immunogen

Synthetic peptide within human hdac1 aa 420-460.

Host

Rabbit

Positive Control

HeLa cell lysate, HEK-293 cell lysate, MCF7 cell lysate, Jurkat cell lysate, L929 cell lysate, C6 cell lysate, HeLa, NIH/3T3, C6, human colon tissue, human pancreas tissue, mouse colon tissue, mouse pancreas tissue, mouse lymph nodes tissue, rat liver tissue, rat pancreas tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

SY12-04

RRID

AB_2889882

APPLICATION DILUTION

  • WB

  • 1:5,000

  • IHC-P

  • 1:50-1:1,000

  • IF-Cell

  • 1:100-1:500

  • IP

  • 1-2μg/sample

  • IF-Tissue

  • 1:50-1:200

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 55 kDa

Isotype

IgG

TARGET

UNIPROT #

Q13547

PROTEIN NAME

HDAC1

SYNONYMS

DKFZp686H12203 antibody;GON 10 antibody;HD1 antibody;HDAC 1 antibody;HDAC1 antibody;HDAC1_HUMAN antibody;Histone deacetylase 1 antibody;Reduced potassium dependency yeast homolog like 1 antibody;RPD3 antibody;RPD3L1 antibody

SEQUENCE SIMILARITIES

Belongs to the histone deacetylase family. HD type 1 subfamily.

TISSUE SPECIFICITY

Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain.

POST-TRANSLATIONAL MODIFICATION

Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1.; Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes. Phosphorylated by CDK5.; Ubiquitinated by CHFR, leading to its degradation by the proteasome. Ubiquitinated by KCTD11, leading to proteasomal degradation.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2 MTA2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.

CITATIONS

  • Professor Ping Fan

    Effect of sodium butyrate on ABC transporters in lung cancer A549 and colorectal cancer HCT116 cells

  • STAT3 phosphorylation mediates high glucose-impaired cell autophagy in an HDAC1-dependent and -independent manner in Schwann cells of diabetic peripheral neuropathy.

  • Jin Tingting,et al

    HDAC1 Promotes Mitochondrial Pathway Apoptosis and Inhibits the Endoplasmic Reticulum Stress Response in High Glucose-Treated Schwann Cells via Decreased U4 Spliceosomal RNA

  • Vitamin A deficiency suppresses CEACAM1 to impair colonic epithelial barrier function via downregulating microbial-derived short-chain fatty acids

  • Sodium butyrate facilitates CRHR2 expression to alleviate HPA axis hyperactivity in autism-like rats induced by prenatal lipopolysaccharides through histone deacetylase inhibition

  • Liu, H., Tan, M., Cheng, B., Wang, S., Xiao, L., Zhu, J., Wu, Q., Lai, X., Zhang, Q., Chen, J., & Li, T.

    Valproic Acid Induces Autism-Like Synaptic and Behavioral Deficits by Disrupting Histone Acetylation of Prefrontal Cortex ALDH1A1 in Rats. Frontiers in neuroscience, 15, 641284.

  • Dr Ben-Jun Wang

    Effects of histone deacetylase inhibitors on ATP-binding cassette transporters in lung cancer A549 and colorectal cancer HCT116 cells

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