Skip to content

Contact

(857) 353-6600

orders@huabio.com

VDAC1 Recombinant Rabbit Monoclonal Antibody [SA93-03] (ET1601-20)

Price: Regular price $385.00

Volume

Bulk Order Quote   |   Customization Request

Catalog# ET1601-20

Rabbit Monoclonal to VDAC1

Tested for

  • WB

  • IF-Cell

  • IHC-P

  • FC

  • IF-Tissue

Reacts with

  • Human

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
Knock-Out or Knock-Down validated
This product has been cited in peer reviewed publications, see list HERE

Safety datasheet

Select your chosen country/region

Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

VDAC1 Recombinant Rabbit Monoclonal Antibody [SA93-03] (ET1601-20)

Immunogen

Synthetic peptide within n-terminal human vdac1.

Host

Rabbit

Positive Control

MDA-MB-231 cell lysate, HeLa cell lysate, K-562 cell lysate, NIH/3T3 cell lysate, PC-12 cell lysate, mouse kidney tissue lysate, HeLa, HepG2, RH-35, human kidney tissue, mouse kidney tissue, rat kidney tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

SA93-03

RRID

AB_3069603

APPLICATION DILUTION

  • WB

  • 1:10,000

  • IF-Cell

  • 1:50-1:100

  • IHC-P

  • 1:1,000

  • FC

  • 1:500-1:1,000

  • IF-Tissue:1:200

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 31 kDa

Isotype

IgG

TARGET

UNIPROT #

P21796

PROTEIN NAME

VDAC1

SYNONYMS

N2441 antibody;OMP2 antibody;POR1 antibody;hVDAC1 antibody;MGC111064 antibody;Mitochondrial Porin antibody;Outer mitochondrial membrane protein porin 1 antibody;Plasmalemmal porin antibody;Porin 31HL antibody;Porin 31HM antibody;VDAC antibody;VDAC-1 antibody;Vdac1 antibody;VDAC1_HUMAN antibody;Voltage dependent anion channel 1 antibody;Voltage dependent anion selective channel protein 1 antibody;Voltage-dependent anion-selective channel protein 1 antibody;YNL055C antibody;YNL2441C antibody

SEQUENCE SIMILARITIES

Belongs to the eukaryotic mitochondrial porin family.

TISSUE SPECIFICITY

Heart, liver and skeletal muscle.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation at Ser-193 by NEK1 promotes the open conformational state preventing excessive mitochondrial membrane permeability and subsequent apoptotic cell death after injury. Phosphorylation by the AKT-GSK3B axis stabilizes the protein probably by preventing ubiquitin-mediated proteasomal degradation.; Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.

SUBCELLULAR LOCATION

Mitochondrion outer membrane, Cell membrane, Membrane raft

FUNCTION

Voltage-dependent anion-selective channel 1 (VDAC-1) is a beta barrel protein that in humans is encoded by the VDAC1 gene located on chromosome 5. It forms an ion channel in the outer mitochondrial membrane (OMM) and also the outer cell membrane. In the OMM, it allows ATP to diffuse out of the mitochondria into the cytoplasm. In the cell membrane, it is involved in volume regulation. Within all eukaryotic cells, mitochondria are responsible for synthesis of ATP among other metabolite needed for cell survival. VDAC1 therefore allows for communication between the mitochondrion and the cell mediating the balance between cell metabolism and cell death. Besides metabolic permeation, VDAC1 also acts as a scaffold for proteins such as hexokinase that can in turn regulate metabolism.

CITATIONS

  • He Jing,et al

    RNAi screens identify HES4 as a regulator of redox balance supporting pyrimidine synthesis and tumor growth

  • Anti-diabetic drug canagliflozin hinders skeletal muscle regeneration in mice

  • Chen, W., Xu, Z., You, W., Zhou, Y., Wang, L., Huang, Y., & Shan, T.

    Cold exposure alters lipid metabolism of skeletal muscle through HIF-1α-induced mitophagy

  • Xu, T., Yu, W., Fang, H., Wang, Z., Chi, Z., Guo, X., Jiang, D., Zhang, K., Chen, S., Li, M., Guo, Y., Zhang, J., Yang, D., Yu, Q., Wang, D., & Zhang, X.

    Ubiquitination of NLRP3 by gp78/Insig-1 restrains NLRP3 inflammasome activation

  • Guo, H., Wei, L., Wang, Y., Cui, H., Deng, H., Zhu, Y., Deng, J., Geng, Y., Ouyang, P., Lai, W., Du, Z., Ni, X., Yin, H., Fang, J., & Zuo, Z.

    Nickel induces hepatotoxicity by mitochondrial biogenesis, mitochondrial dynamics, and mitophagy dysfunction

  • Nanxin Zhang,et al

    Effects and mechanisms of Polygonati Rhizoma polysaccharide on potassium oxonate and hypoxanthine-induced hyperuricemia in mice

  • Chengwei Wu,et al

    NPR1 promotes cisplatin resistance by inhibiting PARL-mediated mitophagy-dependent ferroptosis in gastric cancer

  • Ma Yunhao,et al

    New perspective for Calpain-Mediated regulation of meat Quality: Unveiling the impact on mitochondrial pathway apoptosis in post-mortem

  • Di Wang

    Histone Deacetylase 3 Couples Mitochondria to Drive IL-1β-Dependent Inflammation by Configuring Fatty Acid Oxidation

  • BoyaWu,et al

    Lidamycin induces mitophagy in pancreatic cancer cells by regulating the expression of Mfn2

  • Jiang, H., Chen, F., Song, D., Zhou, X., Ren, L., & Zeng, M.

    Dynamin-Related Protein 1 Is Involved in Mitochondrial Damage, Defective Mitophagy, and NLRP3 Inflammasome Activation Induced by MSU Crystals

Close (esc)

Popup

Use this popup to embed a mailing list sign up form. Alternatively use it as a simple call to action with a link to a product or a page.

Age verification

By clicking enter you are verifying that you are old enough to consume alcohol.

Enter

Search

Main menu

Your cart is currently empty.
Shop now